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中国防痨杂志 ›› 2015, Vol. 37 ›› Issue (3): 307-311.doi: 10.3969/j.issn.1000-6621.2015.03.017

• 综述 • 上一篇    下一篇

脊柱结核合并神经功能障碍的研究进展

唐恺 董伟杰 秦世炳   

  1. 101149  首都医科大学附属北京胸科医院骨科 北京骨关节结核诊疗中心
  • 收稿日期:2015-01-12 出版日期:2015-03-10 发布日期:2015-04-03
  • 通信作者: 秦世炳 E-mail:3848474@163.com
  • 基金资助:

    北京市科技计划课题(D141107005214002)

The development of the spinal tuberculosis with neurological deficit

TANG Kai,DONG Wei-jie,QIN Shi-bing   

  1. Department of Orthopedics, Beijing Chest Hospital, Capital Medical University, Beijing Bone and Joint Tuberculosis Diagnosis and Treatment Center, Beijing 101149, China
  • Received:2015-01-12 Online:2015-03-10 Published:2015-04-03
  • Contact: QIN Shi-bing E-mail:3848474@163.com

摘要: 神经功能障碍是脊柱结核严重的并发症之一,根据其发生机制可分为脊柱结核病变活动型和治愈型(简称“活动型”和“治愈型”)。活动型神经功能障碍的主要病因是硬膜外病变物质对脊髓的机械压迫、脊柱局部骨质破坏产生的后凸畸形或椎间关节脱位,而治愈型患者的病因主要是严重的后凸畸形,脊髓前方横行的骨嵴或是椎管内残留纤维瘢痕增生造成对脊髓的卡压。患者MRI如显示脊髓形态正常或基本正常,仅有炎性水肿,无明显萎缩,则神经功能恢复好;若脊髓形态异常(萎缩、软化、空洞),则神经功能恢复差。对于活动型患者,根据神经功能障碍发生的机制及病程进展特点,进行药物治疗和手术治疗相结合的治疗方案,根据影像学特点选择适宜的手术方式,有利于患者神经功能的早期恢复。对于治愈型神经功能障碍患者,其手术难度大,神经功能恢复差,预防严重的后凸畸形是治疗的关键。

关键词: 结核, 脊柱/外科学, 截瘫, 脊髓压迫症

Abstract: Neurological deficit is one of the most serious complications of the spinal tuberculosis, which is divided into two types: active type and healed type. The main cause of active neurological deficit are mechanical compression on spinal cord by epidural leision, kyphosis or intervertebral joint dislocation developed from spinal bone destruction, while the cause of healed one are serious kyphosis, the compression of spinal cord by hyperplasia of transverse ridge of bone anterior or fibrous scar left in spinal canal. Good neural recovery happened in patients whose MRI shows normal or nearly normal morphology of spinal cord, with inflammatory edema and no obvious atrophy. While poor neural recovery appears in patients with abnormal morphology of spinal cord (atrophy, myelomalacia and cavity).For the active type patients, drug treatment combined with operation according to the mechanism of neural dysfunction and disease progression characteristics and selecting suitable operation procedures according to the imaging characteristics is conducive to the early recovery of nerve function. While for the healed type patients, the operation is difficulty, bad prognosis on nerve functional recovery. Prevention of severe kyphotic is the key to treatment.

Key words: Tuberculosis, spinal/surgery, Paraplegia, Spinal cord compression