关键词: 妊娠并发症,感染性, 结核/药物疗法, 生长和发育, 婴儿

Abstract: Objective  To explore the effects of anti-TB treatment on the growth and development of infants born by mothers who were diagnosed with active TB during terminal stage of pregnancy. Methods  The clinical records, treatment and follow-up materials of 7 maternal active TB cases during terminal stage of pregnancy who were hospitalized in Wuhan TB Center from May 2005 to August 2011 were analyzed. Among them, 6 patients were newly diagnosed TB cases (intensive regimen for 3 of these cases was HRE, for the remaining cases were HRZE, HRZ and HZE respectively), 1 patient was retreatment TB case (intensive regimen for the sole retreatment TB case was INH, PAS, PZA, Lfx, Pto).  Results  The actual treatment duration of these 7 cases ranged from 3 to 12 months, with all cases had experienced obvious relief to the clinical symptoms and all had achieved smear and culture conversion as well, all these improvements were further proven by the marked absorption on the diseased parts shown by their chest X-ray. All 7 patients had given birth to healthy infants without deformities (with 1 premature birth), non infants had infected with utero TB. The results of follow-up observation showed that non of these infants had experienced hearing lose and visual impairment, their language, motor and mental developments were found to be normal. Conclusion  Appropriate and timely anti-TB treatment not only cures maternal active TB cases during terminal stage of pregnancy, but also causes neglectable adverse effects on early childhood growth and development.

Key words: Pregnancy complication,infectious, Tuberculosis/drug therapy, Growth and development, Infant