结核分枝杆菌实验室获得性感染事件分析

中国防痨杂志 ›› 2012, Vol. 34 ›› Issue (5): 333-335.

结核分枝杆菌实验室获得性感染事件分析

陆兵刘秋焕王荣李京京程洪亮陈芳吕京

100071 北京，军事医学科学院生物工程研究所生物安全战略与技术研究室（陆兵、刘秋焕、李京京、程洪亮、陈芳）；中国合格评定国家认可中心四处（王荣、吕京）

收稿日期:2011-09-15 出版日期:2012-05-10 发布日期:2012-05-03
基金资助:
“十一五”国家科技支撑计划（2008BAK42B08）；“十一五”科技重大科技专项（2009ZX10004-501）

Received:2011-09-15 Online:2012-05-10 Published:2012-05-03

摘要/Abstract

摘要： 加强疫苗、结核病新药和诊断方法研究是当前“遏制结核病策略”之一。为此，国家在“十一五”科技重大专项中设立了“艾滋病和病毒性肝炎等重大传染病防治”专项，其中包括结核病防治课题。而在展开结核病防治研究的过程中，如何避免实验室获得性感染则是首先需要解决的问题。本研究收集了20世纪50年代以来国际上文献报道的实验室获得性结核感染事件，并对事件原因进行了分析，以期为我国实验室安全开展Mtb研究提供参考。

陆兵刘秋焕王荣李京京程洪亮陈芳吕京. 结核分枝杆菌实验室获得性感染事件分析[J]. 中国防痨杂志, 2012, 34(5): 333-335.

. [J]. Chinese Journal of Antituberculosis, 2012, 34(5): 333-335.

参考文献

［1］Lalic H, Kukuljan M, Pavicic MD. A case report of occupational middle ear tuberculosis in a nurse. Arh Hig Rada Toksikol, 2010, 61（3）: 333-337.

［2］Leyten EM, Mulder B, Prins C, et al. Use of enzyme-linked immunospot assay with Mycobacterium tuberculosis-pecific peptides for diagnosis of recent infection with M. tuberculosis after accidental laboratory exposure. J Clin Microbiol, 2006, 44（3）: 1197-1201.

［3］Laboratory-acquired tuberculosis- Faulty Aerosol Chamber Infects 3 ［EB/OL］. ［2010-10-20］ http://portland.indymedia.org/en/2005/04/315802.shtml.

［4］Oymak SF, Gülmez I, Demir R, et al. Transmission of Mycobacterium tuberculosis by accidental needlestick. Respiration, 2000, 67（6）: 696-697.

［5］Stenton SC, Hendrick DJ. Occupational tuberculosis and a failed postgraduate medical examination. Occup Med (Lond), 1996, 46（1）: 87-88.

［6］Peerbooms PG, van Doornum GJ, van Deutekom H, et al. Laboratory-acquired tuberculosis. Lancet, 1995, 345（8960）: 1311-1312.

［7］Kao AS, Ashford DA, McNeil MM, et al. Descriptive profile of tuberculin skin testing programs and laboratory-acquired tuberculosis infections in public health laboratories. J Clin Microbiol, 1997, 35（7）: 1847-1851.

［8］Grist NR, Emslie JA. Infections in British clinical laboratories, 1988-89. J Clin Pathol, 1991, 44（8）: 667-669.

［9］Grist NR, Emslie JA. Infections in British clinical laboratories, 1986-87. J Clin Pathol, 1989, 42（7）: 677-681.

［10］Grist NR, Emslie JA. Infections in British clinical laboratories, 1984-85. J Clin Pathol, 1987, 40（8）: 826-829.

［11］Grist NR, Emslie JA. Infections in British clinical laboratories, 1982-83. J Clin Pathol, 1985, 38（7）: 721-725.

［12］Grist NR. Infections in British clinical laboratories, 1980-81. J Clin Pathol, 1983, 36（2）: 121-126.

［13］Shireman PK. Endometrial tuberculosis acquired by a health care worker in a clinical laboratory. Arch Pathol Lab Med, 1992, 116（5）: 521-523.

［14］Sugita M, Tsutsumi Y, Suchi M, et al. High incidence of pulmonary tuberculosis in pathologists at Tokai University Hospital: an epidemiologic study. Tokai J Exp Clin Med, 1989, 14（1）: 55-59.

［15］Lundgren R, Norrman E, Asberg I. Tuberculosis infection transmitted at autopsy. Tubercle, 1987, 68（2）: 147-150.

［16］Wilkins D, Woolcock AJ, Cossart YE. Tuberculosis: medical students at risk. Med J Aust, 1994, 160（3）: 395-397.

［17］Sakula A. Accidental self-inoculation with killed Mycobacterium tuberculosis in Freund’s complete adjuvant. Tubercle, 1977, 58（4）: 221-223.

［18］Engbaek HC, Vergmann B, Bunch-Christensen K. Pulmonary tuberculosis due to BCG in a technician employed in a BCG laboratory. Bull World Health Organ, 1977, 55（4）: 517-520.

［19］Lundgren R, Norrman E, Asberg I. Tuberculosis infection transmitted at autopsy. Tubercle, 1987, 68（2）: 147-150.

［20］Gale GL. Accidental infection with tubercle bacilli in laboratory technicians. Can Med Assoc J, 1957, 76（8）: 646-648.

［21］王宇. 实验室感染事件案例集. 北京: 北京大学医学出版社. 2007: 37-39.

［22］Sewell DL. Laboratory-associated infections and biosafety. Clin Microbiol Rev, 1995, 8（3）: 389-405.