应用免疫抑制剂过程中并发肺结核35例临床分析

中国防痨杂志 ›› 2000, Vol. 22 ›› Issue (1): 36-38.

应用免疫抑制剂过程中并发肺结核35例临床分析

李爱民¹；管霞¹；王豫皖²；

1 郑州铁路局中心医院 450052;2 河南太康县成人中等专科学校;

收稿日期:1998-05-18 修回日期:1998-11-30 出版日期:2000-01-10 发布日期:2000-01-10

Clinicalanalysison 35caseswithpulmonarytuberculosiscomplicatedinapplyingimmunosuppressant

LIAimin ,GUANXia ,WANGYuwan .

ZhengzhouCenterHospitaloftheBureauofRailway 4 5 0 0 5 2

Received:1998-05-18 Revised:1998-11-30 Online:2000-01-10 Published:2000-01-10

摘要/Abstract

摘要： 目的对35例免疫抑制剂应用过程中并发肺结核的临床特点?诊断和治疗进行探讨?方法35例均来自临床,长期或间断应用免疫抑制剂,免疫抑制剂使用距发病时间2～24个月?临床症状及X线表现均不典型?诊断采用细菌学及病理学手段?35例均规则抗痨治疗?结果 35例疗程结束时痰菌阴转率达857%(24/28),X线胸片复查明显吸收485%(16/33),吸收303%(10/33),停药后随访1年无复发,2例在停药半年后死于原发疾病?结论免疫损害宿主并发肺结核,只要规则抗痨,疗程至少一年,均能取得显著疗效?在抗痨中根据原发病病情,适当加用免疫抑制剂,不影响抗痨的疗效?

关键词: 免疫损害, 宿主, 结核,肺

Abstract: Objective Todelveintotheclinicalcharacteristics ,diagnosisandtreatmentofpulmonarytuber culosiscomplicatedinapplyingimmunosuppressanton 35cases.Methods These 35casesareallclinicalpa tients,applyingimmunosuppressantforalongperiodordiscontinuouslyafter 2～ 2 4monthswhenthepatients arepathogenic.ClinicalsymptomsandX -rayhaven'tgivenobviousshow .Diagnosisusesthemeansofpathol ogyandbacteriology .The 35casesareallregularlyantiphthisic.Results Whenthecoursesoftreatmentsof the 35casesfinished ,therateofsputumbacteriatransferingintonegativereached 85 .7% (2 4 / 2 8) ,chestexam inationbyX -rayshowedthat 4 8.5 % (1 6 / 33)wereabsolutelyabsorbedand 30 .3% (1 0 / 33)werepartlyab sorbed .Afterwithdrawal,inthefollow -upsurvey ,therewerenocasesofrecurrenceinoneyearand 2casesof dyingofprimarydiseasesafter 6months.Conclusion Immunocompromisedhostcomplicatedbypulmonary tuberculosiscanbemadetangibletherapeuticeffectivenessifusingregularantiphthisicwithatleastoneyear courseoftreatment.Inaccordancewiththestateoftheprimarydisease,immunosuppressantcanbeappliedap propriatelyandthatwillnotinfluencetheantiphthisiceffectiveness.

Key words: Immunocompromise, Host, Tuberculosis, pulmonary

李爱民, 管霞, 王豫皖, . 应用免疫抑制剂过程中并发肺结核35例临床分析[J]. 中国防痨杂志, 2000, 22(1): 36-38.

LIAimin ,GUANXia ,WANGYuwan .. Clinicalanalysison 35caseswithpulmonarytuberculosiscomplicatedinapplyingimmunosuppressant[J]. Chinese Journal of Antituberculosis, 2000, 22(1): 36-38.

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