关键词: 肺功能, 结核,肺, 血清纤维化指标, Ⅳ型胶原, Ⅲ型前胶原

Abstract: Objective To explore the possibility to use serum fibrosis markers as the diagnostic and remedial index of lung fibrosis in pulmonary tuberculosis. Methods Serum fibrosis markers and pulmonary ventilation function of the selected cases were detected.According to the pulmonary ventilation function,these cases were divided into pulmonary function normal group(group A with 20 cases),pulmonary function mildly decrease group(group B with 35 cases),pulmonary function moderately decrease group(group C with 46 cases) and pulmonary function severely decrease group(group D with 29 cases). Results In group A,the average level of PⅢP,HA,LN,and cⅣ was separately 16±2 ng/ml,88±6 ng/ml,98±15 ng/ml,and 120±26 ng/ml.In group B,that was 19.5±4 ng/ml,92.6±12 ng/ml,102±16 ng/ml,and 141±31 ng/ml.In group C,that was 25.4±4 ng/ml,95±21 ng/ml,111.8±30 ng/ml,and 158±39 ng/ml.In group D,that was 28.9±5 ng/ml,108±18 ng/ml,132±37 ng/ml,and 193±46 ng/ml.Statistical analysis showed that the differences of PⅢP,and cⅣ among the four groups were significant(p<0.001),and the differences between any two groups were significant.The differences of HA and LN among the four groups were mildly significant(p<0.05,p<0.01).Analysing the relationship between forced expiratory volume in one second(FEV_1.0) and cⅣ,PⅢP,HA,LN,the positive correlation was found between FEV1.0,cⅣ,and PⅢP(p<0.05,p<0.01).There was no direct relationship between FEV1.0,HA and LN. Conclusion There is significant correlation between serum fibrosis markers and pulmonary function in pulmonary tuberculosis.Serum fibrosis markers can partially indicate the degree of lung fibrosis.The relationship between cⅣ,PⅢP and lung fibrosis is strongest in all.

Key words: Pulmonary function, Pulmonary tuberculosis, Serum fibrosis markers, cⅣ, PⅢP