妥塞敏治疗肺结核咯血的效果观察

中国防痨杂志 ›› 2008, Vol. 30 ›› Issue (2): 109-113.

妥塞敏治疗肺结核咯血的效果观察

张立兴¹；屠德华¹；肖和平²；王巍³；张金福⁴；张明⁵；

1.中国防痨协会北京 100710；2.上海肺科医院上海 200433；3.解放军总医院附属第二医院北京 100091；4.北京结核病胸部肿瘤研究所北京 101149；5.广州佛山市慢病防治院佛山 528000；

出版日期:2008-02-10 发布日期:2011-11-03

Comparison of the therapeutic effect of tranexamic acid and para-aminomethylbenzoic acid for tuberculosis hemoptysis

hang Lixing¹,Tu Dehua, Xiao Heping,et al.

Chinese Anti-tuberculosis Association,Beijing 100050,China

Online:2008-02-10 Published:2011-11-03

摘要/Abstract

摘要： 目的　比较妥塞敏和止血芳酸治疗肺结核咯血的效果和不良反应。方法于2002—2003年采用前瞻性、随机抽样和多中心研究方法,选入并分析轻度和中度咯血患者118例,其中采用妥塞敏60例、止血芳酸58例。2组性别、年龄、病变、咯血严重程度和咯血史以及合并支气管扩张均相似。结果妥塞敏组和止血芳酸组3日咯血治愈率分别为55%和41.4%(P＞0.05);7日治愈率分别为95%和81%(P＜0.01)。妥塞敏和止血芳酸对初治咯血疗效要优于多次咯血者,无明显不良反应。结论 3日妥塞敏效果与止血芳酸相似,而7日妥塞敏则优于止血芳酸。

关键词: 结核,肺, 咯血, 妥塞敏, 止血芳酸

Abstract: Objective To compare the efficacy and safety of TXA and PAMBA in the treatment of tuberculosis with hemoptysis.Methods A prospective randomized multicenter study was con- ducted from 2002 to 2003.Tuberculosis patients with mild to moderate hemoptysis were assigned to the TXA group(n=60)and the PAMBA group(n=58).The patients were similar with respect to sex and age distribution,history and severity of hemoptysis,and bronchiectasis.Results The cure rates were 55% for the TXA group and 41.4% for the PAMBA group after 3 days of treatment (P>0.05),and 95% and 81% respectively after 7 days of treatment(P<0.01).Either TXA or PAMBA was more effective for patients with new-onset hemoptysis than for those with repeated he- moptysis,without obvious side-effect.Conclusions The therapeutic effect of TXA for tuberculosis hemoptysis was similar to that of PAMBA after 3 days of treatment,but was superior to PAMBA after 7 days of treatment.

Key words: Pulmonary tuberculosis, Hemoptysis, Tranexamic acid, Para-aminomethylbenzoic acid

张立兴,屠德华,肖和平,王巍,张金福,张明,. 妥塞敏治疗肺结核咯血的效果观察[J]. 中国防痨杂志, 2008, 30(2): 109-113.

hang Lixing¹,Tu Dehua, Xiao Heping,et al.. Comparison of the therapeutic effect of tranexamic acid and para-aminomethylbenzoic acid for tuberculosis hemoptysis[J]. Chinese Journal of Antituberculosis, 2008, 30(2): 109-113.

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