左氧氟沙星联合奈替米星治疗耐多药肺结核临床疗效观察

中国防痨杂志 ›› 2004, Vol. 26 ›› Issue (6): 351-353.

左氧氟沙星联合奈替米星治疗耐多药肺结核临床疗效观察

李月龙；矫庆辉；王迓文；刘建木；

吉林市结核病防治研究所吉林 132011；

出版日期:2004-06-10 发布日期:2004-11-03

Clinical analysis of Levofloxacin and Netilmicin in treating Mult i-drug resistant tuberculosis

Li Yuelong,Jiao Qinghui,Wang Yawen,et al.

Jilin City Tuberculos is Institute,Jilin 132011

Online:2004-06-10 Published:2004-11-03

摘要/Abstract

摘要： 目的　观察和评估左氧氟沙星联合奈替米星方案在耐多药肺结核治疗中的疗效。方法 102例耐多药肺结核患者随机分为治疗组52例和对照组50例。治疗组以左氧氟沙星及奈替米星为主,联合力克肺疾、丙硫异烟胺、吡嗪酰胺的化疗方案;对照组以氧氟沙星、力克肺疾、丙硫异烟胺、吡嗪酰胺、乙胺丁醇的化疗方案,疗程为12月。结果全部102例患者完成化疗疗程。治疗组52例,痰菌阴转率86.5%;对照组50例,痰菌阴转率56.0%;痰菌阴转率治疗组明显高于对照组(P<0.01)。结论对耐多药肺结核采用3DNZTHV/9DTHV方案,药物不良反应低,近期治疗效果满意,此方案值得在临床上试用。

关键词: 结核,肺/药物疗法, 结核,抗多种药物性/药物疗法, 氧氟沙星, 奈替米星

Abstract: Objective To observe and evaluate the treatment ef fect of the regimen which contains the Levofloxacin (LVFX) and Netilmicin (NTI) for MDR-TB cases.Methods 102 MDR-TB patients were randomly di vided into two groups.52 cases in the observation group (treated with LVFX,NTI,D ,1321Th,PZA).50 cases in the control group (treated with OFLX,D,1321TH,PZA,EMB). The duration of treatment were 12 months.Results All 102 cases completed their treatment courses.The sputum smear negative conversion rate were 86.5% and 56.0% in the observation group (52 cases) and control group (50 cases ).The rate in observation group was significantly higher than that of the control group (P<0.01).Conclusion It is effective to treating mu lti-drug resistant tuberculosis cases with 3DNZThV/9DThV regimen.The regimen is less adverse reaction recommendable.

Key words: Tuberculosis,pulmonary/drug therapy, Tuberculosis,mut

李月龙,矫庆辉,王迓文,刘建木,. 左氧氟沙星联合奈替米星治疗耐多药肺结核临床疗效观察[J]. 中国防痨杂志, 2004, 26(6): 351-353.

Li Yuelong,Jiao Qinghui,Wang Yawen,et al.. Clinical analysis of Levofloxacin and Netilmicin in treating Mult i-drug resistant tuberculosis[J]. Chinese Journal of Antituberculosis, 2004, 26(6): 351-353.

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