黄石市结核病耐药性监测研究报告

摘要/Abstract

摘要： 目的　按照WHO IUATLD《结核病药物耐药性监测指南》结核病耐药监测技术系统 ,掌握黄石市初始和获得性耐药水平 ,评价结核病控制效果。方法黄石市1999年新发现涂阳病例为本次研究对象。并对全部培养阳性菌株用比例法作H、R、E、S四种药物药敏试验。结果共入选 2 10例 ,其中培养阳性 2 0 0例,培养阴性 8例 ,污染 2例。总耐药率 18.5 % ,初始耐药率 12 .5 % ,初始MDR -TB率 4 .4 % ;获得性耐药率 4 2 .5 %,获得性MDR TB率 2 0 .0 %。结论黄石市结核病耐药流行状况处于国内外监测结果低水平。初步建立了WHO IUATLD结核病耐药性监测系统,获得了黄石市耐药水平资料 ,对评价现行结核病控制策略效果 ,改进防治措施具有重要的必要性和指导性。

关键词: 结核,肺/预防和控制, 分枝杆菌,结核, 耐药, 黄石市

Abstract: Objective To collect the data of initial and acquired drug resistance based the established surveillance system for antituberculous drug resistance according to WHO/IUATLD guidelines,And to evaluate the efficacy of on going tuberculosis control strategies.Methods The study objectives were new detected smear positive pulmonary tuberculosis cases of Huangshi in 1999.Susceptibility tests (proportion method for SM,INH,RFP and EMB) were done in all culture positive specimens.Results 210 patients with pulmonary tuberculosis cases involved in the study.Among of them,200 were culture positive,The culture-positive rate was 95.2% and the culture-negative rate was 3.8%.And the contamination rate was 1.0%.The total drug resistance rate was 18.5%.The initial drug resistance rate was 12.5% and the acquired drug resistance rate was 42.5%.The initial MDR-TB rate was 20%.Conclusion The anti-tuberculosis drug resistant surveillance and quality control system were establisned.The reliable data on the status of anti-tuberculosis drug resistance in Huangshi prefecture were collected.The drug resistance Results provided the evidences for improvement and assessment on TB control measures.

Key words: Tuberculosis,pulmonare/prvention and control, Mycobacterium tuberculosis, Drug resistant, Huangshi

艾义明,黄苓,李国明,吴敏,程玉琴,王欣,肖秋珍,. 黄石市结核病耐药性监测研究报告[J]. 中国防痨杂志, 2004, 26(4): 230-232.

Ai Yiming,Huang Ling,Li Guoming,et al.. Surveillance of drug resistant tuberculosis in Huangshi of China[J]. Chinese Journal of Antituberculosis, 2004, 26(4): 230-232.

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黄石市结核病耐药性监测研究报告

Surveillance of drug resistant tuberculosis in Huangshi of China

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