含阿米卡星及左氧氟沙星方案治疗耐多药肺结核近期疗效观察

摘要/Abstract

摘要： 目的　观察和评估含阿米卡星及左氧氟沙星联合化疗方案在耐多药肺结核治疗中的疗效。方法将 97例耐多药肺结核患者分为治疗组 48例和对照组 49例；化疗方案:治疗组以阿米卡星及左氧氟沙星为主,联合利福喷丁、异烟肼对氨基水杨酸钠、丙硫异烟胺、吡嗪酰胺；对照组用阿米卡星、利副喷丁、异烟肼对氨基水杨酸钠、丙硫异烟胺、吡嗪酰胺,疗程为 21月。结果共有 93例患者完成化疗疗程。治疗组 46例,痰菌阴转率 87%；对照组 47例,痰菌阴转率 59.6%；痰菌阴转率治疗组明显高于对照组 (P＜0.01).结论含阿米卡星及左氧氟沙星方案治疗耐多药肺结核有助于痰菌阴转和病变吸收好转,药物不良反应低,值得在临床上推广应用。

关键词: 结核,肺/药物疗法, 药物耐受性, 阿米卡星, 左氧氟沙星

Abstract: Objective To observe and evaluate the treatment effect of the regimen which contains the Amikacin (AK) Sulfate and the Lexofloxacin (LVFX) for MDR-TB cases.Methods 97 MDR-TB patients were randomly divided into two groups.48 cases in the observation group (treated with AK,LVFX,DL-473,Pa,PZA,Pt),49 cases in the control group (treated with AK,DL-473,Pa,PZA,Pt).The duration of treatment was 21 months.Results 93 cases completed their treatment.The sputum smear negative conversion rate was 87% and 59% in the observation group (46 cases) and control group (47 cases).The rate in observation group was significantly higher than that of the control group (P＜ 0.01).Conclusion The regimen which contains Amikacin Sulfate and Levofloxacin was helpful to the sputum smear negative conversion and the absorption of the athology and with lower side reaction,this regimen deserve to be popularized in the practice.

Key words: Pulmonary tuberculosis/Chemotherapy, Multi-drug resistant (MDR), Amikacin, Levofloxacin

高春荣,袁东运,徐立江,. 含阿米卡星及左氧氟沙星方案治疗耐多药肺结核近期疗效观察[J]. 中国防痨杂志, 2004, 26(3): 165-167.

Gao Chunrong,Yuan Dongyun,Xu Lijiang.. The short-term treatment effect of regimen which contains the Amikacin Sulfate and the Levofloxacin for multi-drug resistant pulmonary tuberculosis cases (MDR-TB)[J]. Chinese Journal of Antituberculosis, 2004, 26(3): 165-167.

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含阿米卡星及左氧氟沙星方案治疗耐多药肺结核近期疗效观察

The short-term treatment effect of regimen which contains the Amikacin Sulfate and the Levofloxacin for multi-drug resistant pulmonary tuberculosis cases (MDR-TB)

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