1992—2004年住院肺结核病例耐药性分析

中国防痨杂志 ›› 2006, Vol. 28 ›› Issue (6): 390-392.

1992—2004年住院肺结核病例耐药性分析

刘相¹；陈海峰²；吕翠环¹；杜月菊¹；王淑平¹；高官聚¹；

1河北省胸科医院石家庄 050041；2河北省疾病预防控制中心石家庄 050011；

出版日期:2006-06-10 发布日期:2006-11-03

Analysis of drug resistance of Mycobacterium tuberculosis in hospitalized tuberculosis cases from 1992 to 2004

Liu Xiang,Chen Hafeng,Lv Cuihuan,et al.

Hebei provincial chest hospital,Shijiazhuang 050041,China

Online:2006-06-10 Published:2006-11-03

摘要/Abstract

摘要： 目的分析了解1992、1996、2000、2004年结核分枝杆菌的耐药性。方法采用绝对浓度间接法进行8种药物的敏感试验。结果1992、1996、2000、2004年耐药率分别为59.6%、76.3%、70.5%5、0.8%;初治耐药率分别为51.9%、79.9%、70.4%、40.4%;复治耐药率分别为76.8%、67.5%、70.8%、77.2%。耐单药率以INH、RFP、SM 3药较高。耐多种药率以SR、HR、SHR、SRE、SHRE较高。结论结果显示结核病的耐药情况相当严重,对结核病的临床治疗和管理应给予足够的重视。

关键词: 结核,肺/流行病学, 抗药性,细菌, 住院病人

Abstract: Objective To analyze the drug resistance of Mycobacterium tuberculosis in 1992,1996,2000 and 2004 respectively. Method Absolute concentration method was carried out for Mycobacterium drug sensitivity in 8 anti-tuberculosis drugs. Results The rate of drug resistance to all drugs were 59.6%,76.3%,70.5% and 50.8% respectively;the rate of initial resistance were 51.9%,79.9%,70.4% and 40.4% respectively;acquired resistance rate were 76.8%,67.5%,70.8% and 77.2%.The rate of drug resistance to INH,RFP and SM were higher than that to other drugs,the rate of drug resistance to SR,HR,SHR,SRE,SHRE combination were higher. Conclusion The Results show that the drug resistance of mycobacterium is rather serious in hospitalized patients,and more attention should be paid to management and treatment for the tuberculosis patients.

Key words: Pulmonary tuberculosis/epidemiology, Drug resistance,germ, Inpatients

刘相,陈海峰,吕翠环,杜月菊,王淑平,高官聚,. 1992—2004年住院肺结核病例耐药性分析[J]. 中国防痨杂志, 2006, 28(6): 390-392.

Liu Xiang,Chen Hafeng,Lv Cuihuan,et al.. Analysis of drug resistance of Mycobacterium tuberculosis in hospitalized tuberculosis cases from 1992 to 2004[J]. Chinese Journal of Antituberculosis, 2006, 28(6): 390-392.

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