大连市结核病控制对策与结核病耐药趋势

中国防痨杂志 ›› 2003, Vol. 25 ›› Issue (4): 219-222.

大连市结核病控制对策与结核病耐药趋势

杨晓明；路希伟；

大连市结核病医院大连 116011；

出版日期:2003-04-10 发布日期:2003-11-03

Research on the rend of drug resistance of the smear positive tuberculosis and tuberculosis control project

Yang xiao-ming,LU Xi-wei.

Dalian Tuberculosis Control Center,Dalian 116011

Online:2003-04-10 Published:2003-11-03

摘要/Abstract

摘要： 目的　评价 1993—2000年大连市结核病防治效果及结核分支杆菌的耐药率趋势。方法对疫情统计资料进行分析 ,采用绝对浓度间接法对 4种药物进行耐药测定。结果 1993—2000年DOTS坚持率分别为 7.0%、27.0%、41.4%、35.1%、68.4%、73.8%、77.6%、89.6%。涂阳治愈率分别为 54.0%、67.1%、73.2%、84.3%、91.0%、93.5%、94.0%、92.7%。初始耐药率由 1993—1994的 34.6%下降至 1999—2000年的 18.2% ,获得性耐药率由 1993—1994年的 52.1%下降至 1999—2000年的 35.7%。结论大连市初始及获得性耐药率均呈下降趋势。归口管理和实行DOTS策略是耐药率下降的主要原因。

关键词: 结核,肺/预防和控制, 抗药性/微生物, 大连市

Abstract: Objective To evaluate 1993—2000 Dalian tuberculosis prevention and treatment result and the trend of drug resistance of the smear positive tuberculosis.Methods Statistics the date to proceed the brigade row the analysis to epidemic situation.All of the strains of M .tuberculosis from new register smear positive tuberculosis were test for resistance to INH,RFP,EMB and SM by absolute concentration methods.Results In 1993—2000 DOTS persistence rate were 7.0%,27.0%,41.4%,35.1%,68.4%,73.8%,77.6%,89.6% respectively.The cure rate were 54.0%,67.1,73.2%,84.3%,91.1%,93.5%,94.0%,92.7% respectively.The rate of initial resistance was declined from 34.6% in 1993—1994 to 18.2% in 1999—2000.The rate of acquired resistance declined form 52.1% in 1993—1994 to 35.7% in 1999—2000.Conclusion The rate of initial and acquired resistance was declined.The main reason is due to the convergence case-management and the DOTS strategy.

Key words: Tuberculosis,pulmonary/prevention and control, Drug resistance,microbial, Dalian

杨晓明,路希伟,. 大连市结核病控制对策与结核病耐药趋势[J]. 中国防痨杂志, 2003, 25(4): 219-222.

Yang xiao-ming,LU Xi-wei.. Research on the rend of drug resistance of the smear positive tuberculosis and tuberculosis control project[J]. Chinese Journal of Antituberculosis, 2003, 25(4): 219-222.