结核病DNA疫苗的现状与未来

摘要/Abstract

摘要： 1990年Wolff等^[1]在一次基因治疗的实验研究中意外地发现不加任何处理的基因也可在骨骼肌细胞中表达蛋白至少2月，从而产生了核酸疫苗或基因疫苗、基因免疫、核酸免疫的全新概念，开创了免疫学和疫苗学的新领域。核酸疫苗包括DNA疫苗和RNA疫苗，由能引起机体保护性免疫反应的病原体抗原的编码基因和真核表达载体构建而成，它被注入机体后，通过宿主细胞的转录系统表达蛋白抗原，诱导宿主产生细胞免疫应答和体液免疫应答，从而达到预防和治疗疾病的目的。

吴雪琼,金关甫,. 结核病DNA疫苗的现状与未来[J]. 中国防痨杂志, 2003, 25(5): 329-333.

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