关键词: 结核,肺, 乙型肝炎, 白介素-2

Abstract: Objective To improve the curative effect and reduce side effect in the treatment of smear-positive pulmonary tuberculosis accompanying hepatitis B.Methods Use Interleukin-2(IL-2) in a daily dose of 20000 U supplemented with 2SHRZ/4H₃R₃ for 50 patients and contrast with 23 patients treated by 2SHRZ/4H₃R₃ and ordinary liver-curing medicine.Results The sputum negative conversion rates,HBeAg and HBV-DNA from positive to negative of the active group after 6 months themotherapy were 96.0%,70.4% and 71.4% respectively,which is obviously higher than 65.3%,8.3%and 14.3% of the control group (P<0.01).In the meantime,both the hepatic damage rate and drug withdrawal rate of the former were 0,Which is also obviously lower than the latter 26.1%(P<0.01),the recurrence rate of sputum,the conversion rates of HBeAg and HBV-DNA from positive to negative of the active group were 0,10.5% and 10.0% and the rates of control group were 6.7%,0,50.5% respectively according to a two-year follow-up examination,which indicatng less difference between active and control groups.Conclusion IL-2 is effective in antituberculosis,inhibit of reproduction of hepatitis B virus,as well as in reliving liver pathological process and reducing hepatic damage by antituberculous drugs.

Key words: Tuberculosis,pulmonary, Hepatitis B, Interleukin-2(IL-2)