以ESAT-6、CFP-10为基础的ELISPOT 试验、血清TB-SA抗体检测、PPD试验在肺结核诊断中应用价值研究

中国防痨杂志 ›› 2009, Vol. 31 ›› Issue (7): 434-436.

以ESAT-6、CFP-10为基础的ELISPOT 试验、血清TB-SA抗体检测、PPD试验在肺结核诊断中应用价值研究

邱丽华¹；王学东¹；周洪顺¹；岳淼¹；王立华¹；郝金拄¹；王海英¹；薛付忠²；刘志敏¹

1. 山东省胸科医院济南 250013；2. 山东大学公共卫生学院济南 250012

出版日期:2009-07-10 发布日期:2011-11-03

Online:2009-07-10 Published:2011-11-03

摘要/Abstract

摘要： 免疫学技术是结核分枝杆菌感染的重要诊断方法。血清结核抗体的检测已作为结核病诊断辅助指标之一^[1]，TB-SA（tuberculosis-specific antigen）抗体检测在肺结核诊断中具有较高的敏感性和特异性^[2]；PPD皮肤试验已被卫生部生物制品标化委员会规定可临床诊断的参考指标^[3]；近年来以结核菌特异蛋白ESAT-6（6KD early secretory antigenictarget）、CFP-10（culture filtrate protein10）为基础的酶联免疫斑点试验（ELISPOT TEST）在结核感染诊断中的应用价值已被许多相关研究所证实^[4-6]。

邱丽华,王学东,周洪顺,岳淼,王立华,郝金拄,王海英,薛付忠,刘志敏. 以ESAT-6、CFP-10为基础的ELISPOT 试验、血清TB-SA抗体检测、PPD试验在肺结核诊断中应用价值研究[J]. 中国防痨杂志, 2009, 31(7): 434-436.

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