2型糖尿病合并肺结核治疗中诺和锐30和诺和灵30R的疗效观察

中国防痨杂志 ›› 2008, Vol. 30 ›› Issue (4): 287-290.

2型糖尿病合并肺结核治疗中诺和锐30和诺和灵30R的疗效观察

金周德；于关成；张智勇；孙集思

长春市传染病医院长春 130123

出版日期:2008-04-10 发布日期:2011-11-03

Contrast research of NovoRapid 30 and Novolin 30R in treating T2DM complicated with pulmonary tuberculosis

Jin Zhoude,Yu Guancheng,Zhang Zhiyong,et al.

Changchun Communicable Disease Hospital Department of Diabetease,Changchun 130123,China

Online:2008-04-10 Published:2011-11-03

摘要/Abstract

摘要： 目的比较诺和锐30和诺和灵30R每日2次皮下注射治疗开始胰岛素治疗的2型糖尿病(T₂DM)合并肺结核患者的疗效和安全性。方法随机、开放的比较观察12周。60例T₂DM合并肺结核患者被随机分为诺和锐30治疗组和诺和灵30R治疗组,采用每日早、晚餐前2次皮下注射方案,观察2组患者7个时点血糖、糖化血红蛋白(HbA_1C)、低血糖反应及其他不良反应观察2组治疗后痰菌转阴情况及肺结核病灶X线变化。结果诺和锐30治疗组3餐后血糖水平明显低于诺和灵30R治疗组(P<0.05);诺和锐30组低血糖发生次数低于诺和灵30R组,严重低血糖发生次数为诺和灵30R组的55.5%;2组HbA_1c、胰岛素用量及其他不良反应无显著性差异。诺和锐30组治疗后痰菌转阴率为90.4%,诺和灵30组痰菌转阴率为75%,2组有显著性差异(P<0.05),2组患者治疗后肺部病灶改善例数分别为19、18例,2组比较有显著性差异。结论T₂DM合并肺结核患者采用早、晚餐前预混胰岛素皮下注射方案治疗时,诺和锐30对餐后血糖控制更为满意,且低血糖反应发生率少,对痰菌转阴更为有效。可应用于开始胰岛素治疗的广大T₂DM合并肺结核患者。

关键词: 诺和锐30, 诺和灵30R, 2型糖尿病, 结核,肺

Abstract: Objective To compare NovoRapid 30 with Novolin 30R in curative effect and security in treating type 2 diabetes mellitus complicated with pulmonary tuberculosis. Method The contrast observation was conducted randomly and openly for 12 weeks,60 patients of T₂DM complicated with pulmonary tuberculosis were divided into two groups.One group was treated by NovoRapid 30 and the other by Novolin 30R.All of them used in the way of hypodermic injection before breakfast and dinner,the blood sugar for 7 times a day was measured and HbA_lC and low blood sugar response and other side effects were also observed.In addition to this,sputum conversion and chest X-ray were observed. Result The level of blood sugar of using NovoRapid 30 after three meals was lower obviously than that of Novolin 30R(P<0.05),the rate of low blood sugar of NovoRapid 30 was lower than that of Novolin 30R,and the rate of serious low blood sugar of NovoRapid 30 was 55% of Novolin 30R,HbA_lC,amount of of the use of insulin and other side effects of the two groups have no statistically significant difference.The rate of sputum conversion rate of NovoRapid 30 was 90.4%,and that of Novolin 30R was 75%.There was statistically significant difference between the two groups(P<0.05).The number of the cases with absorption of chest X-ray of NovoRapid 30 was 19 and that of Novolin 30R was 18.There was no statistically significant difference between them. Conclusion The effect of NovoRapid 30 in controlling blood sugar after breakfast and dinner is more satisfied than that of Novolin 30R.The rate of low blood sugar is lower,and the rate of sputum conversion is higher.Thus,to select NovoRapid 30 to treat T₂DM complicated with pulmonary tuberculosis is better than Novolin 30R.

Key words: NovoRapid 30, Novolin 30R, T₂DM complicated, pulmonary tuberculosis

金周德,于关成,张智勇,孙集思. 2型糖尿病合并肺结核治疗中诺和锐30和诺和灵30R的疗效观察[J]. 中国防痨杂志, 2008, 30(4): 287-290.

Jin Zhoude,Yu Guancheng,Zhang Zhiyong,et al.. Contrast research of NovoRapid 30 and Novolin 30R in treating T2DM complicated with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2008, 30(4): 287-290.