关键词: 结核,肺/预防和控制, 化学疗法, 固定剂量复合剂

Abstract: Objective To study the feasibility of using fixed-dose combinations in Provincial Tuberculosis(TB) Programe. Method According to the registered serial number,the new smear-positive pulmonary TB cases were distributed into study group(odds number) and control group(even number).The treatment success rate,treatment outcome,patients’ compliance and side-effect were analyzed in the two groups. Result There was no significant difference between the two group on sex,age,weight,treatment success rate,management method and patients’ compliance(P>0.05).The sputum conversion rate at the end of 2 nd month and 3 rd month were 87.0% and 93.5% in study group,and were 89.4% and 93.5% in the control group.The cure rate was 93.5% in the study group and 87.0% in the control group.The difference on the treatment outcome between the two groups was not statistically significant(P>0.05).Except for tinnitus caused by streptomycin(Fisher’s exact P=0.024),other side-effect caused by anti-TB drug were not significant different between the two groups(P>0.05). Conclusion In the developed area,applying fixed-dose combination in regional TB programe is feasible.

Key words: Pulmonary tuberculosis/prevention and control, Chemotherapy, Fixed-dose combination