关键词: 结核,肺/药物疗法, 肝损害

Abstract: Objective To observe the clinical efficacy and safety of the treatment regimen of’Pasiniazid, Rifapentine, Amikacin and Levofloxcin’ for lesions of the liver caused by tuberculosis. Methods By random group-matching,100 cases with lesions of the liver caused by tuberculosis were divided into the treatment group(50 cases) and control group(50 cases).The chemotherapy regimen adopted: the treatment group used Pasiniazid(D),Rifapentine(L),Amikacin(K) and Levofloxcin(V) while the control group used Isoniazid(H), Rifampicin(R), Amikacin(K), and Pyrazinamide(Z).The course of treatment was 9 months for both groups. Results Ninty-six cases completed the treatment with 49 cases in the treatment group and 47 cases in the control group.In the treatment group,the sputum negative conversion rate by the end of the 9^th month was 95.0% in smear and 96.4% in culture;while in the control group,the rates were 94.4% and 95.7% respectively.At the end of the treatment,X-rays evidently improved the assimilation of focuses up to 98.0% in the treatment group and 97.9% in the control group;the ratios of cavity closure reached respectively 61.5% and 57.1%;there was no significantdifference in the treatment outcome in the two groups(P＞0.05).The re-checking in 2 years showed that the positive conversion rate was 3.7% in treatment group and 4.5% in control group with no significant different between the two groups.The lesions of the liver was 32.0% in the treatment group and 58.0% in the control group with significant difference in the two groups(P＜0.01). Conclusion The regimen of ’DLKV’ scheme is effective and reliable to cure lesions of the liver caused by tuberculosis and it is easy to expand the application of this regimen in the clinical practice.

Key words: Pulmonary tuberculosis/drug therapy, Liver lesion