浙江省湖州市区结核病耐药趋势分析

中国防痨杂志 ›› 2006, Vol. 28 ›› Issue (2): 103-105.

浙江省湖州市区结核病耐药趋势分析

徐德顺；张思潮；杨俊超；

浙江省湖州市疾病预防控制中心湖州 313000；

出版日期:2006-02-10 发布日期:2006-11-03

The analysis on the trend of drug resistance of tuberculosis in Huzhou city,Zhejiang

Xu Deshun.Zhng Sichao.YANG Jun-chao.

Huzhou City Center For Disease Prevention and Control.Huzhou 313000,China

Online:2006-02-10 Published:2006-11-03

摘要/Abstract

摘要： 目的掌握湖州市区结核病耐药动态及变化趋势,评价结核病控制实施效果。方法对2001—2004年痰涂片阳性的新发初治肺结核病人和复治病人进行痰结核分枝杆菌培养,阳性菌株采用比例法进行四种抗结核药物耐药性测试。结果总耐药率由2001年30.0%下降至2004年的21.8%,初始耐药率由2001年的23.6%下降至2004年的16.5%,继发耐药率由2001年61.5%下降至2004年的47.2%,不同耐药类型呈下降趋势。结论湖州市区耐药率呈下降趋势。归口管理和实行DOTS策略可能是耐药率下降的主要原因。

关键词: 结核,肺, 抗药性,细菌

Abstract: Objective To determine the dynamic changes and trend of drug resistance of tuberculosis and to evaluate the effect of tuberculosis control program.Methods To cultivate Mycobacterium tuberculosis in the sputa with a positive smear test result of new and re-treat patients with tuberculosis.Drug susceptibility testing was tested in the culture positive strains against four anti-tuberculosis drugs by using the proportional method from 2001 to 2004.Results The rate of total drug resistance was declined from 30.0% in 2001 to 21.8% in 2004.The rate of initial resistance was declined from 23.6% in 2001 to 16.5% in 2004.The rate of acquired resistance was declined from 61.5% in 2001 to 47.2% in 2004.The rate of different drug resistance was declined.Conclusion The rate of initial and total drug resistance was declined.The main reason is due to convergence case-management and the implementation of DOTS strategy.

Key words: Pulmonary tuberculosis, drug resistance,bacterial

徐德顺,张思潮,杨俊超,. 浙江省湖州市区结核病耐药趋势分析[J]. 中国防痨杂志, 2006, 28(2): 103-105.

Xu Deshun.Zhng Sichao.YANG Jun-chao.. The analysis on the trend of drug resistance of tuberculosis in Huzhou city,Zhejiang[J]. Chinese Journal of Antituberculosis, 2006, 28(2): 103-105.