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中国防痨杂志 ›› 2005, Vol. 27 ›› Issue (5): 333-335.

• 论著 • 上一篇    下一篇

SARS患者血清中ADA、β2-微球蛋白和SA含量的研究

易小萍1；罗晓红2；张院良1；许蕴怡1；谢敏娜1；   

  1. 1.广州市胸科医院；广州 510095；2.中山大学孙逸仙纪念医院；广州 510120；
  • 出版日期:2005-05-10 发布日期:2005-11-03

A Study on the concentration of ADA、β2-MG and SAin patients with SARS

Yi Xiaoping,Luo Xiaohong,Zhang Yuanliang,et al.   

  1. Guangzhou Chest Hospital,Guangzhou510095,China
  • Online:2005-05-10 Published:2005-11-03

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摘要： 目的　探讨测定严重急性呼吸困难综合征(SARS)病人血清中腺苷脱氢酶(ADA)、β2-微球蛋白(β2-MG)和唾液酸(SA)含量,评价其机体的免疫反应状况及组织损害程度。方法 对105例SARS患者测定血清中ADA、β2-MG和SA水平;检测方法,ADA采用速率法,β2-MG采用散射比浊法;SA采用酶法,同时与肺结核和普通型肺炎血清作比较。结果 (1)SARS病人血清中ADA水平明显低于肺结核组,有显著性差异(P<0.001)。而在SARS患者的WBC计数大于5.0×109/L与低于5.0×109/L2组中其含量有显著性差异(P<0.001),(2)β2-MG,SARS病人明显高于肺结核和普通型肺炎患者有显著性差异(P<0.001);同时在SARS病人中,年龄越大其水平越高。(3)SARS病人血清中SA水平明显高于结核和普通型肺炎病人,有显著性差异(P<0.001);而在SARS患者中WBC计数小于3.0×109/L其水平较高。结论 检测ADA、β2-MG和SA含量可作为评价SARS病人机体的免疫反应状况和组织损害程度的一项参考指标。

关键词: 严重急性呼吸困难综合证, 腺苷脱氢酶, β2-微球蛋白, 唾液酸

Abstract: Objective: To determinate the concentration of adenosine deaminase(ADA)、β2-microglobulin(β2-MG) and saliva acid(SA) in patients withsevere acute respiratorysyndrome(SARS) and evaluate the immunore-action and degree of damage caused by severe acute respiratory syndrome virus.Method Serumsamples of thepatients with SARS,pulmonary tuberculosis(TB) or normal pneumonia(NP) were collected and the levels ofADA、β2-MGand SAwere detected separately.Results(1)As to the ADAlevel,SARS group was obviouslylower thanthe TBgroup(P<0.001) while among SARS patients,the result was different withthe total amountof WBChigher or lower than 5.0×109/l in which the higher group has more ADAproduction than the lowergroup.(2)As totheβ2-MGlevel,SARS group was higher thanthe TBgroup or the NPgroup while it rise withthe age inthe SARS patients.(3)The SAconcentrationinthe SARS group was higher thanthe TB group or theNPgroup while the result was different withthe total amount of WBChigher or lower than 3.0×109/Lin whichthe lower group patients produced more SAthanthe higher group.Discussion: The concentration of ADA、β2-MGand SAcan be used as a set of parameterto evaluatetheimmunoreactionand degree of damage caused byse-vere acute respiratory syndrome virus.

Key words: SARS, ADA, β2-MG, SA

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