复方甘草甜素联合还原型谷胱甘肽治疗48例抗结核药物性肝炎的疗效分析

摘要/Abstract

摘要： 目的　探讨复方甘草甜素和还原型谷胱甘肽对结核药物性肝炎的临床疗效。方法采用前瞻性研究,对2001年1月—2004年12月诊断为抗结核药物性肝炎48例住院患者随机分为治疗组和对照组,前者予复方甘草甜素和还原型谷胱甘肽治疗,后者进行常规治疗,疗效进行χ²统计学分析。结果结核药物性肝炎大多发生于强化期内,临床表现为恶心、呕吐,严重者出现乏力、纳差、黄疸、腹胀、肝区疼痛及肝大,复方甘草甜素和还原型谷胱甘肽的疗效显著优于对照组。结论复方甘草甜素和还原型谷胱甘肽治疗1周内可明显改善药物性肝炎表现及恢复肝功能作用,对于结核药物性肝炎有较高疗效,而且临床应用安全。

关键词: 结核,肺/药物疗法, 肝炎, 复方甘草甜素, 还原型谷胱甘肽

Abstract: Objective To explore the therapeutic effect of compound glycyrrhizin and reductive glutathione on the hepatitis suffered from anti-tuberculous drugs.Method Prospective study was adopted.Fourty-eight inpatients suffered from hepatitis resulted from antituberculous drugs during Jan,2001 and Dec,2004 were randomly sorted out into treatment group and control group.The former was treated with compound glycyrrhizin and reductive glutathione,but the latter was treated with routine drugs.The effect was analysized byχ² test.Results Most inpatients of hepatitis occurred during the enhanced period.The clinical manifestations were followed as nausea or vomit.Either tiredness,icterus,windy feeling,pain in liver,or augment of liver might be happened in severe cases.Drug hepatitis was often resulted from the secondary pulmonary tuberculosis or extra-pulmonary tuberculosis.The effect at treatment group was markedly excelled than the control.Conclusion Compound glycyrrhizin and reductive glutathione not only were able to alleviate the clinical manifestations of drug hepatitis within one week,but also able toimprove liver function.Compound glycyrrhizin and reductive glutathione were characteristic of both safe and well therapeutic effect on the hepatitis suffered from antituberculous drugs.

Key words: Pulmonary tuberculosis/chemotherapy, hepatitis, compound glycyrrhizin, reductive glutathione

杨松,张耀亭,殷建团,. 复方甘草甜素联合还原型谷胱甘肽治疗48例抗结核药物性肝炎的疗效分析[J]. 中国防痨杂志, 2005, 27(5): 327-329.

Yang Song,Zhang Yaoting,Yin Jiantuan.. Therapeutic effect of compound glycyrrhizin and reductive glutathione on the fourty-eight inpatients suffered from hepatitis resulted from anti-tuberculous drugs[J]. Chinese Journal of Antituberculosis, 2005, 27(5): 327-329.

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复方甘草甜素联合还原型谷胱甘肽治疗48例抗结核药物性肝炎的疗效分析

Therapeutic effect of compound glycyrrhizin and reductive glutathione on the fourty-eight inpatients suffered from hepatitis resulted from anti-tuberculous drugs

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