艾滋病合并结核病患者的免疫功能临床研究

摘要/Abstract

摘要： 目的　了解艾滋病 (AIDS)合并结核病患者的免疫功能受损情况和治疗转归。方法分析1997年5月—2004年 3月住院的 11例AIDS合并结核病患者的CD4、CD8、HIV-RNA及PPD试验并与同期住院结核病 31例和AIDS 27例相比较。结果 AIDS合并结核病组、AIDS组与结核病组比较则CD4、CD8有显著性差异、CD3无显著性差异,而AIDS合并结核病与AIDS比较CD3、CD4、CD8均无显著性差异。 11例AIDS合并结核病中 6例检测HIV-RNA＞3.0×10⁶ copy/ml,5例HIV-RNA＜3.0×10⁶ copy/ml。而 27例AIDS中 3例HIV-RNA＞3.0×10⁶ copy/ml,24例HIV-RNA＜3.0×10⁶ copy/ml,比较有显著性差异。结论 AIDS合并结核病者免疫功能严重受损,与结核病比较差异显著,但与AIDS比较则无明显差异。合并结核病者HIV-RNA较未合并者高,说明合并结核病者病毒复制量大,尤其是当AIDS合并血行播散性肺结核者死亡率高,抗结核治疗疗效差。

关键词: 艾滋病, 结核,肺/并发症, 免疫功能

Abstract: Objective To investigate the damage of immune functions in AIDS complicated with pulmonary tuberculosis and to analysis the relationship between AIDS and tuberculosis to treat and prognosis.Methods Retrospective analysis was performed in 11 cases AIDS complicated with pulmonary tuberculosis patients hospitalized from May 1997 to March 2004 cases were tested T-lymphocyte subpopulation, PPD test and HIV-RNA. These tests Results were compared with 27 AIDS cases and tuberculosis 31 cases in the same time hospitalized.Results The CD4 and CD8 cell level in peripheral blood was statistical significance difference (P＜0.01) in the AIDS with tuberculosis, and AIDS than tuberculosis.The CD3 cell level was no statistical significance (P＞0.05). 6 cases HIV-RNA viral content in AIDS with tuberculosis was＞3.0×10⁶ copy/ml,5 cases HIV-RNA viral content＜3.0×10⁶ copy/ml.It was statistical significance (P＜0.01)that it was compared with AIDS 27 cases (3cases＞3.0×10⁶ copy/ml,24cases＜3.0×10⁶ copy/ml). ALL patients alive expect for two patients dead of blood distribution of pulmonary tuberculosis.Conclusion The immune functions of AIDS complicated with tuberculosis were severe destroyed.The mortality was high in ADIS complicated blood distribution of pulmonary tuberculosis and terminal AIDS complicated with pulmonary tuberculosis. The study found AIDS complicated diffusion by blood of pulmonary tuberculosis and terminal AIDS complicated with pulmonary tuberculosis viral content was high, infective was serious, harm was verse. Treatment effect of anti-tuberculous was poor.

Key words: AIDS, Pulmonary tuberculosis/complicotion, Immune Function

刘艳,余卫业,王晓燕,乐晓华,李慧涓,胡毅文,王辉,陆普选,. 艾滋病合并结核病患者的免疫功能临床研究[J]. 中国防痨杂志, 2005, 27(1): 47-50.

Liu Yan,Yu Weiye,Wang Xiaoyan,et al.. The clinic study of the immune functions in AIDS complicated with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2005, 27(1): 47-50.

[1]	谭守勇吴碧彤林兆原黎燕琼. 免疫干预治疗对老年肺结核细胞免疫及低蛋白血症影响[J]. 中国防痨杂志, 2011, 33(4): 254-256.
[2]	刘明. 艾滋病合并肺结核30例临床分析[J]. 中国防痨杂志, 2011, 33(3): 179-180.
[3]	马立新苏志敏杨桦张青剑郭富爱张彦亭孙家麟. 河北省石家庄市肺结核病人 HIV筛查结果分析[J]. 中国防痨杂志, 2011, 33(3): 194-194.
[4]	胡嘉, 邱林西, 陈伟, 张慧, 舒奇, 王黎霞, 袁辉. 江西省6个县(区)结核患者HIV感染现状分析[J]. 中国防痨杂志, 2010, 32(12): 831-834.
[5]	赵丁源, 叶建君, 熊昌富, 周丽平, 候双翼, 罗军民, 杨成凤, 王小靖, 刘勋, 李爱国. INH预防性治疗PPD试验阳性的HIV/AIDS患者的效果分析[J]. 中国防痨杂志, 2010, 32(11): 772-773.
[6]	李月华, 吴刚, 马依夏提·马合木提. 新疆第五轮全球基金结核病/艾滋病双重感染防治项目效果评价[J]. 中国防痨杂志, 2010, 32(11): 767-769.
[7]	谭守勇, 邝浩斌. 肺结核继发肺真菌感染的诊治进展[J]. 中国防痨杂志, 2010, 32(10): 71-74.
[8]	卢瑞朝,徐彩玲,李琦,. HIV/AIDS合并肺结核54例死亡病因分析[J]. 中国防痨杂志, 2007, 29(4): 314-316.
[9]	金克群,. 艾滋病合并肺结核129例临床分析[J]. 中国防痨杂志, 2005, 27(1): 51-53.
[10]	吕康言,梁树学,. 艾滋病合并肺结核24例分析[J]. 中国防痨杂志, 2004, 26(5): 280-282.
[11]	孙燕芝,余卫业,付向东,王辉,张瑛,李少珍,. 中药蛇蝎对颈结核性淋巴结炎患者免疫功能影响及疗效观察[J]. 中国防痨杂志, 2004, 26(3): 142-144.
[12]	王卫华,赵恒敏,张和武,. 艾滋病合并结核病的临床分析[J]. 中国防痨杂志, 2003, 25(5): 316-317.
[13]	李丙喜,王林,周新华,. 艾滋病合并肺结核21例临床分析[J]. 中国防痨杂志, 2003, 25(1): 21-23.
[14]	郑素华,端木宏瑾,李拯民,冯惠忠,张福杰,崔为国,陈明朝,余为业,朱林,谭爱军,. 人类免疫缺陷病毒(HIV)感染者结核菌素试验反应的研究[J]. 中国防痨杂志, 2002, 24(6): 320-323.

艾滋病合并结核病患者的免疫功能临床研究

The clinic study of the immune functions in AIDS complicated with pulmonary tuberculosis

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