Pulmonary tuberculosis incidence and its influencing factors in rural areas of Xiangtan county，Hunan province

Abstract

Abstract: Objective To study the pulmonary tuberculosis incidence and risk factors among rural areas. Methods A nested case-control study was conducted based on cohort of 72 859 subjects in Xiangtan county of Hunan province. The case group was composed of 80 cases of new tuberculosis patients detected during the 1 year follow-up program. Four hundred nontuberculosis subjects were selected by simple random sampling method from the cohort as controls. Univariate analysis and mutivariate nonconditional logistic regression were used to analyze associations between the exposure factors and pulmonary tuberculosis. Results The incidence of pulmonary tuberculosis was 109 80 per 100 000（80/72 859） within one year, the incidence of male and female was 168.11（63/37 476），48.05 per 100 000 （17/35 383） respectively. The results of univariate analysis showed that age (Wald χ²=22.251，P<0.001，OR=1.759), gender (Wald χ²=16.145，P<0.001，OR=0.310), educational level (Wald χ²=21.937，P<0.001，OR=0.468), marital status (Wald χ²=8.320，P=0.004，OR=0.358), occupation (Wald χ²=10.297，P=0.001，OR=0.377), history of TB exposure (Wald χ²=7.535，P=0.006，OR=4.166), history of tuberculosis (Wald χ²=14.637，P<0.001，OR=57.000), smoking history (Wald χ²=4.525，P=0.033，OR=1.730), suspicious symptoms (Wald χ²=46.630，P<0.001，OR=12.758) were significantly associated with TB incidence; multivariate analysis showed that gender (β=-1.142，Wald χ²=12.904，OR=0.319，95% CI=0.171-0.595), education level (β=-0.743，Wald χ²=14.355，OR=0.476，95% CI=0.324-0.699), marital status (β=-1.138，Wald χ²=7.537，OR=0.320，95%CI=0.142-0.722), history of tuberculosis (β=2.852，Wald χ²=5.563，OR=17.329，95%CI=1.619-185.441), suspicious symptoms (β=1.728，Wald χ²=16.333，OR=5.630，95%CI=2.435-13.016) were significantly associated with TB incidence. Conclusion Women, high education level and single were protective factors of TB incidence while history of tuberculosis and suspicious symptoms of tuberculosis were risk factors of TB incidence.

Key words: Tuberculosis, pulmonary/epidemiology, Incidence, Risk factors, Hunan province

ZHANG Chuan-fang, ZHANG Yi-rui, CHEN Tian-zhu, GONG De-hua, ZHAO Pei-an, ZENG Zheng-biao, TANG Yi, BAI Li-qiong. Pulmonary tuberculosis incidence and its influencing factors in rural areas of Xiangtan county，Hunan province[J]. Chinese Journal of Antituberculosis, 2012, 34(11): 731-735.

References

［1］Sullivan T, Ben Amor Y.The co-management of tuberculosis and diabetes: challenges and opportunities in the developing world. PLoS Med, 2012, 9(7): e1001269.

［2］World Health Organization.Global tuberculosis control 2011. Geneva:World Health Organization,2011:12.

［3］World Health Organization．Global tuberculosis control：surveillance，planning financing：WHO report 2008．Geneva：World Health Organization，2008．

［4］王宇.全国第五次结核病流行病学抽样调查资料汇编.北京：军事医学科学出版社，2011.

［5］达泽蛟，祝秉东，张颖.结核病免疫机制及疫苗研究进展.微生物与感染,2011,6(3)：169-178.

［6］国杰.西藏自治区复治涂阳肺结核病人发生原因分析.中国防痨杂志，2008，30（6）：551-552.

［7］杨建安，阚晓宏.肺结核病发病影响因素流行病学调查研究.安徽医学，2002，2(4)：53-54.

［8］王国杰，Adrian Sleigh,周刚,等.成年人肺结核病的非生物危险因素病例对照研究.中华流行病学杂志，2005,26(2)：92-96.

［9］陈伟，王雪静，王黎霞,等.全国五省结核病与性别关系的研究.中国防痨杂志，2010,32(9)：534-539.

［10］陈梦施，杨华林，陈艳芳,等.湖南省HIV/AIDS人群结核发病影响因素的巢式病例对照研究.中华流行病学杂志,2010,31（2）：151-154.

［11］Davila S, Hibberd ML, Hari Dass R,et al. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet，2008，4(10):e1000218.

［12］蒋学峰,刘芳,高玉婧,等.银川市结核发病危险因素病例对照研究. 中华预防医学杂志，2008，42（2）：90-92.

［13］Faurholt-Jepsen D, Range N, Praygod G，et al. Diabetes is a risk factor for pulmonary tuberculosis: a case-control study from Mwanza, Tanzania. PLoS One, 2011,6(8):e24215.

［14］叶真，丛黎明，丁钢强,等. 浙江省成人糖尿病患病率调查.中华内分泌代谢杂志，2011，27(12):988-994.

［15］张宁梅，李德云，吴先萍,等.四川省城乡居民糖尿病流行特征.中国慢性病预防与控制，2007,15(5):462-464.

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