Abstract: Objective To study the resistance of OFLX of in patients of pulmonary tuberculosis.Methods Retrospective investigation of 205 cases with pulmonary tuberculosis from Jan.1993 to Dec.1995 in our hospital.All cases were sputum culture positive and possessed drug susceptibility test rusults.Results The result showed that 11 cases(17.5%)occurred secondary resistance,2 cases(1.4%) occurred primary resistance.The analysis of patients with OFLX resistant bacilli suggests that long time administration of anti TB drugs and equivalent to monotherapy with OFLX are the causes of secondary resistance and infected by OFLX resistant bacilli may be associated with primary resistance.In addition,the therapeutic effects of OFLX sensitive cases are remarkably superior to OFLX resistant cases.Conclusion OFLX is a new and effective anti tuberculosis drug for it's effect and low rate.

Key words: Tuberculosis, pulmonary, Ofloxacin, Drug Resistance