CD4+CD25+ regulatory T cell suppressed the adaptive immunity in patients with 
pulmonary tuberculosis

Abstract

Abstract: Objective To investigate the suppressive activity of CD4⁺CD25⁺ regulatory T cell on cellular immune response and its potential contribution to pathogenesis of pulmonary tuberculosis.Methods The regulatory function of CD4⁺CD25⁺T cells on cellular response including cell proliferation,cytokine IFN-γ and IL-10 production in patients with active tuberculosis was assayed through isolation of CD4⁺CD25⁺T cells from peripheral blood mononuclear cells(PBMC).Results Depletion of CD4⁺CD25⁺T cells did not increase the cellular proliferation response of PBMC from healthy donors to BCG restimulation,but did result in significant increase of BCG stimulated cell proliferation,IFN-γ and IL-10 production in patients with pulmonary tuberculosis.In addition,isolated CD4⁺CD25⁺T cells from patients with pulmonary tuberculosis significantly suppressed the cell proliferation,IFN-γ and IL-10 production of CD4⁺CD25^-T cells in response to BCG stimulation.Conclusions CD4⁺CD25⁺T cells suppressed Mycobacterium tuberculosis immunity and therefore may contribute to the pathogenesis of tuberculosis.

Key words: Pulmonary tuberculosis, CD4⁺CD25⁺ regulatory T cell, Immuno-regulation

Chen Xinchun,Zhou Boping,Deng Qunyi,et al.. CD4⁺CD25⁺ regulatory T cell suppressed the adaptive immunity in patients with pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2008, 30(3): 165-169.

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