Abstract: Objective To analyze the drug resistance trend of Mycobacterium tuberculosis in Nanjing region. Method Absolute concentration method was used to detect the sensitivity of the 10 most used mycobacterium drugs. Results Resistance rate of each anti-tuberculosis drug fluctuated in some range, while resistance rate to multi-drug increased year by year. The resistant rate to first-line anti-tuberculosis drugs was fairly higher than to second-line anti-tuberculosis drugs. Conclusion The trend of resistance rate has been a serious threat to current therapy protocol of tuberculosis. It was imperative that new generation anti-tuberculosis drugs, with little adverse effect, should be developed to solve current dilemma of tuberculosis therapy.

Key words: tuberculosis, drug resistance, Nanjing