Abstract: Objective To make use of Methods of molecular epidemiology to evaluate the comprehensive effect of tuberculosis control under the implementation of the quality control of DOTS strategy in tuberculosis. Methods Retrospective study was adopted to research the positive sample of tuberculosis patients by the molecular epidemiology, as well as to investigate patients clustered to look for the epidemiology link. Results During the period of a study of molecular epidemiology under the implementation of the quality control of DOTS strategy in tuberculosis, in terms of the MIRU-VNTR examination, the cluster rate was 70%,of which the Shandong cluster accounted for 22%, and the proportion was significantly decreased compared with it was in 2002(P<0.005); the epidemiological correlation rate was 32.5%. Conclusion The Results of the study of molecular epidemiology would be one of the Methods to evaluate the effectiveness as the Objective under the implementation of quality control of DOTS strategy in tuberculosis.

Key words: mycobacterium tuberculosis, tuberculosis/epidemiology, tuberculosis/prevention and control