Abstract: Objective To collect the data of initial and acquired drug resistance based the established surveillance system for antituberculous drug resistance according to WHO/IUATLD guidelines,And to evaluate the efficacy of on going tuberculosis control strategies.Methods The study objectives were new detected smear positive pulmonary tuberculosis cases of Huangshi in 1999.Susceptibility tests (proportion method for SM,INH,RFP and EMB) were done in all culture positive specimens.Results 210 patients with pulmonary tuberculosis cases involved in the study.Among of them,200 were culture positive,The culture-positive rate was 95.2% and the culture-negative rate was 3.8%.And the contamination rate was 1.0%.The total drug resistance rate was 18.5%.The initial drug resistance rate was 12.5% and the acquired drug resistance rate was 42.5%.The initial MDR-TB rate was 20%.Conclusion The anti-tuberculosis drug resistant surveillance and quality control system were establisned.The reliable data on the status of anti-tuberculosis drug resistance in Huangshi prefecture were collected.The drug resistance Results provided the evidences for improvement and assessment on TB control measures.

Key words: Tuberculosis,pulmonare/prvention and control, Mycobacterium tuberculosis, Drug resistant, Huangshi