Abstract:

To deal with the serious challenge of the epidemic of tuberculosis (TB) epidemic, a major infectious disease that endangers global human health, there is urgent need to develop an effective new TB vaccine. Although lots of types of new TB vaccines are currently being developed, and some of vaccines have entered clinical trials, a more effective new TB vaccine that can replace the traditional BCG vaccine has not yet been obtained. With the breakthrough of mRNA vaccine development technology, its advantages of short development cycle, high efficiency, safety and low production cost make it a very promising new direction of vaccine research and development. In this paper, the research progress of the technical principle, advantages and preparation techniques of mRNA vaccine, and the development strategy and the current situation of TB-mRNA vaccine was reviewed, so as to provide reference for the development of TB-mRNA vaccine.

Key words: Mycobacterium tuberculosis, RNA, bacterial, RNA, messenger, Vaccines, inactivated, Games, experimental, Review