Research progress of programmed cell death protein 1/programmed cell death ligands signaling pathway in immune regulation of tuberculosis

doi:10.19982/j.issn.1000-6621.20220127

Abstract

Abstract:

Programmed cell death protein 1 (PD-1) and programmed cell death ligands (including programmed cell death ligand 1 (PD-L1) and PD-L2) are inhibitory costimulatory molecules, which plays an important role in the immune response of tuberculosis. This article reviewed the structure and function of PD-1/PD-L1, PD-L2 and its immune-regulatory role in pulmonary alveolar macrophage and T cell subsets, different types of tuberculosis and different treatment stages of tuberculosis, in order to provide new ideas for the diagnosis and treatment of tuberculosis.

Key words: Immunoglobulins, Ligands, Tuberculosis, Immunity, Review literature

CLC Number:

R52
R392

Liu Qi, Liang Jianqin. Research progress of programmed cell death protein 1/programmed cell death ligands signaling pathway in immune regulation of tuberculosis[J]. Chinese Journal of Antituberculosis, 2022, 44(10): 1085-1090. doi: 10.19982/j.issn.1000-6621.20220127

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