卡介苗接种对体液免疫的影响及其临床意义

中国防痨杂志 ›› 1999, Vol. 21 ›› Issue (1): 39-40.

卡介苗接种对体液免疫的影响及其临床意义

王仲元；匡铁吉；李伟霞；宋萍；张寅；金关甫；

解放军309医院；

收稿日期:1998-01-16 修回日期:1998-05-20 出版日期:1999-01-10 发布日期:1999-01-10

Influence of BCG vaccination on humoral immunity of human beings and its clinical significance

Wang Zhongyuan,Kuang Tieji,Li Weixia,et al.

The 309th Hospital of PLA,Beijing 100091

Received:1998-01-16 Revised:1998-05-20 Online:1999-01-10 Published:1999-01-10

摘要/Abstract

摘要： 目的观察卡介苗接种(简称种卡)与体内抗结核抗体变化间的关系?方法测定53例新兵种卡前及种卡后第12周和第24周时血清中抗PPD抗体(PPD IgG)的OD值并与种卡前进行对比分析?结果53例新兵种卡前PPD IgG2例(3.8%)阳性,种卡12周后15例(28.3%)阳性,种卡24周后9例(17.0%)阳性,抗PPD抗体OD值种卡后第12周较种卡前明显升高(P<0.001)?结论接种卡介苗后PPD IgG水平升高说明种卡可以提高机体对结核菌的体液免疫水平,且可在较长时间内维持,这对于儿童活动性结核病的血清学诊断结果可能会产生干扰作用。

关键词: 结核病, 卡介苗, PPD-IgG, 体液免疫

Abstract: Objectives To observe the influence of BCG vaccination on the humoral immunity to tuberculosis bacilli.Methods The serum antibodies to PPD(PPD IgG) of 53 recruits were measured before and after BCG vaccination(12 and 24 weeks later).The OD value of them was compared between 3 measurements.Results Before BCG vaccination,there were 2 cases(3.8%) with positive PPD IgG,At the 12th week after BCG vaccination,there were 15(28.3%)positive;Followed by next 12 weeks,there were 9(17.0%)positive.The OD value of PPD IgG was higher significantly after BCG vaccination,compared with that before(P<0 001).Conclusions The increasing of PPD IgG after BCG vaccination shows that it can boost human beings humoral immunity to tuberculosis bacilli and keep that at a high level.This may interfere with the serological diagnosis of active tuberculosis among children.

Key words: Tuberculosis, BCG, PPD, IgG

王仲元, 匡铁吉, 李伟霞, 宋萍, 张寅, 金关甫, . 卡介苗接种对体液免疫的影响及其临床意义[J]. 中国防痨杂志, 1999, 21(1): 39-40.

Wang Zhongyuan,Kuang Tieji,Li Weixia,et al.. Influence of BCG vaccination on humoral immunity of human beings and its clinical significance[J]. Chinese Journal of Antituberculosis, 1999, 21(1): 39-40.

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