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中国防痨杂志 ›› 2001, Vol. 23 ›› Issue (5): 291-293.

• 论著 • 上一篇    下一篇

大连市实施世行贷款项目以来耐药结核病流行趋势研究

路希伟；谌杰；张洪娟；刘晶华；   

  1. 辽宁省大连市结防中心 大连 116011；
  • 出版日期:2001-05-10 发布日期:2001-11-03

Research on the trend of drug resistance of the smear positive tuberculosis of tuberculosis control project loaned by the world-bank

LU Xi-wei,SHEN Jie,ZHANG Hong-juan,et al.   

  1. Dalian Tuberculosis Control Center,Dalian 116011
  • Online:2001-05-10 Published:2001-11-03

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摘要： 目的　观察1993～2000年结核分支杆菌的耐药率流行趋势。方法 采用绝对浓度间接法对4种药物进行耐药测定。结果 初始耐药率由1993～1994的34.6%下降至1999～2000年的18.2%，链霉素和异烟肼的初始耐药频率由1993～1994年的22.6%、13.2%下降至1999～2000年的13.4%、7.8%；复治耐药率由1993～1994年的52.1%下降至1999～2000年的35.7%。MDR的总耐药率1993～1994年为9.5%，1999～2000年的7.6%。结论 大连市开展世行贷款项目以来初始及复治耐药率均呈下降趋势，但MDR的总耐药率未出现明显下降。

关键词: 分支杆菌,结核, 耐药性, 监测

Abstract: Objective To observe the epidemic trend of drug resistance of the smear positive tuberculosis in 1993～2000.Methods All of the strains of M.tuberculosis from new register smear positive tuberculosis were tested for resistance to INH RFP EMB SM by absolute concentration methods.Results The rate of initial resistance declined from 34.6% in 1993～1994 to 18.2% in 1999～2000.The resistance rate to SM and INH declined from 22.6%,13.2%in 1993～1994 to 13.4%,7.8% in 1999～2000 respectively.The rate of the acquired resistance declined from 52.1% in 1993～1994 to 35.7% in 1999～2000. The total drug resistance rate of MDR was 9.5% in 1993～1994 and 7.6% in 1999～2000.Conclusion The rate of initial and the acquired drug resistance was declined.The total rate of drug resistance of MDR did not decline.

Key words: M.tuberculosis, Drug resistance, Surveillance

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