深圳市耐多药结核病人管治效果初步评价

中国防痨杂志 ›› 2009, Vol. 31 ›› Issue (5): 256-258.

深圳市耐多药结核病人管治效果初步评价

谭卫国¹；邓伟忠¹；赵梅桂²；管红云¹；杨应周¹

1.深圳市慢性病防治中心深圳 518020；2.深圳市宝安区慢性病防治院深圳 518020

出版日期:2009-05-10 发布日期:2011-11-03

Evaluation on management and treatment of MDR-TB patients in Shenzhen

Tan Weiguo¹, Deng Weizhong¹, Zhao Meigui², Guan Hongyun¹,Yang Yingzhou¹

1.Shenzhen Center for Chronic Disease Prevention and Control, Shenzhen 518020, China；2.Chronic Disease Prevention and Control of Baoan District, Shenzhen 518020, China

Online:2009-05-10 Published:2011-11-03

摘要/Abstract

摘要： 目的分析深圳市耐多药肺结核的诊断、治疗、管理及其效果，并为制定耐多药肺结核病防治对策提供参考依据。方法政府提供专项经费；确保结核分枝杆菌实验室的质量保障；确保一、二线抗结核药物的供应； DOT管理的患者接受免费的一、二线抗结核药物、治疗监测和DOT管理服务；全程管理服务的患者接受免费的治疗监测。结果2003—2006年，共有111例接受治疗，出现不良反应率60.4%，治疗成功率59.5%,丢失率18.9%,失败率11.7%； 48例耐多药肺结核病人接受DOT免费管理，治愈34例，治愈率70.8%。63例耐多药肺结核病人接受自费的全程管理，治愈22例，治愈率34.9%。结论逐步推行DOTS-plus策略，可提高耐多药肺结核的治愈率，减少耐药结核的传播。

关键词: 结核, 肺/预防和控制, 结核, 肺/药物疗法, 结核, 抗多种药物性/预防和控制, 结核, 抗多种药物性/药物疗法, 评价研究, 深圳市

Abstract: Objective To evaluate the diagnosis, treatment and management of MDR-TB cases in Shenzhen city and to provide scientific evidence for MDR-TB control and prevention. MethodsGovernment provided special fund. The quality of the TB laboratory was guaranteed. The supply of the first-line and second-line anti-tuberculosis drugs was ensured. Patients treated under DOT were supplied with free first-line and second-line anti-tuberculosis drugs, treatment surveillance and DOT management. Patients treated under whole course management were provided free treatment surveillance. ResultsOne handred and eleven MDR-TB cases were treated from 2003 to 2006. Side-effect rate was 60.4%, treatment success rate was 59.5%, default rate was 18.9% and failure rate was 11.7%. 48 of all were treated under DOT, 33of whom were cured. The cured rate was 70.8%. Sixty-three of all were treated under whole course management, 22 of whom were cured. The cured rate was only 34.9%. ConclusionsDOTS-plus strategy should be implemented increasingly in all population, so that to control the spread of DR-TB.

Key words: pulmonary tuberculosis/prevention & control, pulmonary tuberculosis/drug therapy, tuberculosis,multidrug-resistant/prevention & control, tuberculosis,multidrug-resistant/drug therapy, evaluation studies, Shenzhen city

谭卫国,邓伟忠,赵梅桂,管红云,杨应周. 深圳市耐多药结核病人管治效果初步评价[J]. 中国防痨杂志, 2009, 31(5): 256-258.

Tan Weiguo¹, Deng Weizhong¹, Zhao Meigui², Guan Hongyun¹,Yang Yingzhou¹. Evaluation on management and treatment of MDR-TB patients in Shenzhen[J]. Chinese Journal of Antituberculosis, 2009, 31(5): 256-258.

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