Abstract: Objective To study the clinical efficacy and safety of pulmonary tuberculosis complicated with severe pneumonia treated by linezolid. Methods Fifty cases of patients with pulmonary tuberculosis complicated with severe pneumonia, who were admitted to our hospital from March, 2010 to September, 2012, diagnosed by clinical data were retrospectively analyzed, in which the efficacy by linezolid was summarized and the values in leukocyte number, neutrophil count, C-reactive protein, erythrocyte sedimentation rate, platelets and serum creatinine were compared between before and after treatment. The paired t test was used for analysis of the enumeration data, in which P<0.05 was considered statistically significance. Results In 50 patients with pulmonary tuberculosis complicated with severe pneumonia treated by linezolid, both the bacteria elimination rate and clinical cure rates were 82.0%(41/50). Their leukocyte number, neutrophil count, C-reactive protein, erythrocyte sedimentation before treatment were （14.52±6.88）×10⁹/L,（12.44±7.01）×10⁹/L，（112.28±82.59）μg/L and （66.28±37.71）mm/1h, respectively before treatment and were（9.94±3.43）×10⁹/L,（7.64±3.46）×10⁹/L，（57.19±59.23）μg/L and （50.56±27.15）mm/1h, respectively after treatment. There were significant differences between before and after treatment, in which t values were 4.214, 4.345, 3.163 and 2.098 and all P values were less than 0.05. The platelets count before treatment was（306.54±150.94）×10⁹/L and after treatment was（259.18±140.39）×10⁹/L, in which t value was 1.625, P value was 0.107; The blood creatinine concentrations were （104.88±118.54）μmol/L before treatment, （118.15±122.18）μmol/L after treatment, in which t value was －0.535, P value 0.594. No statistical differences were found between before and after treatment in platelets count and blood creatinine concentrations (all P values ＞0.05). Conclusion It is safe and effective for the patients with pulmonary tuberculosis complicated with severe pneumonia treated by linezolid, which can be used as empirical medication.

Key words: Tuberculosis, pulmonary/complications, Pneumonia, Acetamides, Oxazolidinones, Treatment outcome