Abstract:

Objective To observe the clinical effect of Chaizhushigao Decoction in recurrent fever tuberculosis complicated with other infections. Methods We collected the clinical data of 29 patients who were hospitalized in the tuberculosis department of institute for tuberculosis research, the 8th Medical Center of Chinese PLA General Hospital from March 2016 to March 2018 and were diagnosed as secondary tuberculosis complicated with other non-tuberculosis infections. These patients had clear evidence of bacteriological infection and still suffered from fever continuously or repeatedly after routine anti-tuberculosis and antiinfection treatment at different times. They were treated with Chaizhushigao Decoction (self-made prescription), and at same time the antibiotics against other bacterial infections were stopped with informed consent of all patients. The antipyretic effect of the treatment with Chaizhushigao Decoction afer 7 days and the long-term effect of 2 months after discharge were observed. These patients were treated with antituberculous drug for 1 to 6 months, with an average of (2.0±1.8) months; with anti-infection drug for 7 to 180 days, with an average of (43.3±36.6) days; and fever duration was 10 days to 6 months, with an average of (20.0±4.0) days. Results Of 29 tuberculosis patients treated with Chaizhushigao Decoction for 7 days, 20 (69.0%) patients were completely controlled, 6 (20.7%) patients were partially controlled, 2 (6.9%) patients were effective, 1 (3.4%) patient was ineffective, and the total effective rate was 96.6% (28/29). Among 26 (89.7%) patientswith complete and partial control, 12 (46.2%) patients recovered to normal temperature within 3 days, 8 (30.8%) patients recovered to normal temperature within 3 to 5 days, and 6 (23.1%) patients recovered to normal temperature within 5 to 7 days. And the temperature of these patients did not recur after one month of drug withdrawal. Among the 2 effective patients, their body temperature patient decreased to normal on the 9th and 10th day of taking medicine, respectively, but their body temperature fluctuated to about 37.5 ℃ after repeated observation, and the body temperature returned to normal after one month’s treatment with traditional Chinese medicine. After another antifungal treatment, the body temperature of one invalid patient gradually returned to normal 2 months later. Conclusion Chaizhushigao Decoction has a good clinical effect in the treatment of recurrent fever tuberculosis complicated with other infections. Its antipyretic mechanism needs further study in clinical practice.

Key words: Tuberculosis, Bacterial infections, Comorbidity, Fever, Medical futility, Medicine,Chinese traditional, Treatment outcome, Chaizhushigao decoction