Abstract: Objective  To study the effects of blood concentration of 2 anti-tuberculosis drugs, levofloxacin (Lfx) and pyrazinamide (PZA) in pulmonary tuberculosis patients with diabetes.  Methods  The levels of serum Lfx and PZA were measured by high performance liquid chromatography (HPLC) in pulmonary tuberculosis patients with diabetes, and compared with patients without diabetes. The data were calculated by SPSS 13.0 software. The drug concentration of Lfx and PZA were analyzed in pulmonary tuberculosis patients with diabetes, and compared with patients without diabetes.  Results  The drug concentration of Lfx was higher in pulmonary tuberculosis patients with diabetes than that in the patients without diabetes, (8.03±2.60) μg/ml and (6.66±1.76) μg/ml，t=2.39，P=0.02）. There was no significant difference between the 2 groups on the drug concentration of PZA((14.24±4.79) μg/ml and (14.86±5.74) μg/ml；t=0.37，P=0.71).  Conclusion  The drug peak concentrations of Lfx were affected by the factors of diabetes. The peak drug concentrations of PZA were not affected by diabetes.

Key words: Tuberculosis, pulmonary/complications, Diabetes complications, Antitubercular agents, Plasma concentation, Chromatography, high pressure liquid