Research and progress of PK/PD for anti-tuberculosis drugs

doi:10.3969/j.issn.1000-6621.2019.06.020

Abstract

Abstract:

Tuberculosis treatment requires a combination of multiple drugs and long-term treatment, therefore, it is urgent to develop new anti-tuberculosis drugs. The research and development of new anti-tuberculosis drugs are inadequate. Exploring the pharmacokinetic/pharmacodynamics (PK/PD) of existing drugs in vitro and in vivo and optimizing the use of anti-tuberculosis drugs are essential to improve treatment efficacy and reduce the occurrence of drug-resistant tuberculosis. This article reviewed the PK/PD research methods and characteristics of anti-tuberculosis drugs PK/PD, in order to provide reference for clinical optimization of anti-tuberculosis treatment.

Key words: Antitubercular agents, Pharmacokinetics, Dose-response relationship, drug, Review litera-ture as topic

Jiao-jie ZHAO,Yu LU. Research and progress of PK/PD for anti-tuberculosis drugs[J]. Chinese Journal of Antituberculosis, 2019, 41(6): 700-704. doi: 10.3969/j.issn.1000-6621.2019.06.020

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