Abstract: Abstract：Objective  To investigate the antituberculosis therapeutic methods, regimen, course and efficacy judgment for multidrug-resistant tuberculous meningitis. Methods  Four tuberculous meningitis cases with multidrug-resistant tuberculosis isolated from cerebrospinal fluid were analyzed retrospectively in our hospital in recent years and relevant literatures were reviewed. Results  Four patients were treated with individual anti-TB therapeutic regimen and combined with intrathecal injection with isoniazid and dexamethasone. Two patients had been cured and drug withdrawal and the others were dead due to serious complications or adverse drug reaction. Conclusion  Tuberculous meningitis cases with multidrug-resistant tuberculosis usually are serious disease, rapid deterioration and high mortality. There is no uniform therapeutic regimen to treat at present.

Key words: Tuberculosis,meningeal/drug therapy, Drug resistance,multiple,bacterial, Treatment outcome