Abstract: Objective Research on the calculation formula of need for Fixed-dose combination drugs (FDCS) in NTP and estimative parameter, which will be shared by drug management systems of other diseases.  Methods Based on the calculation method of FDCS’s need, recommended by WHO, and the local FDCS’s characteristic, and the experience on drug supplying in china, obtain the calculation formula of need for Fixed-dose combination drugs (FDCS); the parameter for need calculation was obtained from 484 new smear positive cased by measure their weight and non-negative conversion rate at the end of second month and drug refuse rate.  Results Calculation formula: HRZ: X×（A_30-39×180+A_30-39×R×90+A _40-49×240+A_40-49×R×120+A₅₀×300+A₅₀×R×150）×1.25.streptomycin: X×（22.5+11.25×R）×1.25.HR X×（A_30-39×180+A _40-49×180+A₅₀×240）×1.25. the loose drug:X×B×1.25.; parameter: south provinces:the proportion of 30～39 kg is 5.88%（2.89%，8.87%）, the proportion of 40～49 kg is 40.34%(34.10%，46.57%), the proportion of more than 50 kg patient  kg is 53.78%(47.45%，60.12%).North provinces the proportion of 30～39 kg is 3.67%（1.32%，6.03%）, the proportion of 40～49 kg is 21.63%（16.48%，26.79%）, the proportion of more than 50 kg patient is 74.69%（69.25%，80.14%）. non-negative conversion rate at the end of second month is 5.47％（3.46％，7.47％）. drug refuse rate is 2.69％（1.25％，4.13％）. Conclusion The calculative principle and formula has special reference to estimating the drug need in NTP, and be shared with other drug’s supply system.

Key words: tuberculosis,pulmonary/drug therapy, antitubercular agents, fixed-dose combination drugs, algorithms