Abstract: Objective To study the effects of anti-trberculosis drugs on liver functions of the tuberculosis patients complicated with hepatitis B virus(HBV)and hepatitis C virus(HCV)infectious.Methods Both groups of the tuberculosis patients complicated with HBV and HCV,and group of Tuberculosis patient without HBV and HCV complicated infectious were treated with an identical regimen of chemotherapy of anti-tuberculosis.The liver functions of patients in both groups were observed and compared during the courses of anti-trberculosis therapy.Results The liver injury rate in the group with complicated HBV and HCV was(50.0%)significantly higher than that in the patients without HBV and HCV complicated infectious(7.7%)(P<0.01),and the time of liver injury occurred and time for liver function to restore were also significantly different(P<0.05,P<0.01).However,The injury degree was not significantly different(P>0.05).Conclusion The incidence of liver injury of the tuberculosis patients complicated with both HBV and HCV is high,early occurred,and restore slow.During the anti-tuberculosis therapy ,but the injury degree maybe mild .It is necessary,however,to monitor liver function for those patients in a short period.

Key words: Tuberculosis,pulmonary, Hepatitis B and C virus Marker, Drug therapy