Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (5): 465-471.doi: 10.3969/j.issn.1000-6621.2020.05.010
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ZHAO Ben-nan, LIU Da-feng(), LIU Ya-ling, YANG Ming, LAN Li-juan, DU Qing
Received:
2020-02-04
Online:
2020-05-10
Published:
2020-05-08
Contact:
LIU Da-feng
E-mail:ldf312@126.com
ZHAO Ben-nan, LIU Da-feng, LIU Ya-ling, YANG Ming, LAN Li-juan, DU Qing. Clinical analysis of hypothyroidism after anti-tuberculosis treatment in patients with multidrug-resistant tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(5): 465-471. doi: 10.3969/j.issn.1000-6621.2020.05.010
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药品 | 剂量及用法 |
---|---|
吡嗪酰胺(Z) | 1.5g/次,1次/d,口服 |
左氧氟沙星(Lfx) | 0.75g/次,1次/d,口服 |
莫西沙星(Mfx) | 0.4g/次,1次/d,口服 |
阿米卡星(Am) | 0.4g/次,1次/d,肌内注射或静脉滴注 |
环丝氨酸(Cs) | 0.25g/次,2次/d,口服 |
丙硫异烟胺(Pto) | 0.3g/次,2次/d,口服 |
对氨基水杨酸(PAS) | 8~10g/d,分3~4次服用,口服或静脉滴注 |
氯法齐明(Cfz) | 0.2g/次,1次/d,口服;12周后减量至0.1g/次,1次/d |
利奈唑胺(Lzd) | 0.6g/次,1次/d,口服 |
贝达喹啉(Bdq) | 前2周0.4g/次,1次/d,口服;2周后减量至0.2g/次,疗程6个月 |
特征 | 患者例数 (336例) | 甲状腺功能[例(构成比,%)] | χ2值 | P值 | |
---|---|---|---|---|---|
甲减症(97例) | 正常(239例) | ||||
组别 | 5.020 | 0.025 | |||
Pto组 | 91 | 18(19.78) | 73(80.22) | ||
Pto+PAS组 | 245 | 79(32.24) | 166(67.76) | ||
年龄组(岁) | 0.935 | 0.627 | |||
18~ | 124 | 34(27.42) | 90(72.58) | ||
40~ | 153 | 48(31.37) | 105(68.63) | ||
60~65 | 59 | 15(25.42) | 44(74.58) | ||
性别 | 6.772 | 0.009 | |||
男 | 216 | 52(24.07) | 164(75.93) | ||
女 | 120 | 45(37.50) | 75(62.50) |
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