Abstract:

Objective To evaluate the drug compliance effect of TB patients by application of intelligent electronic medicine box and mobile phone WeChat APP supervision drug management tool.Methods Since October 3,2017 to March 15, 2018, according to the purposive sampling method, Anda City and Lanxi County of Suihua City of Heilongjiang Province, Changqing District and Jiyang County of Jinan City of Shandong Province were selected as the research site by National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention. In accordance with the registration sequence and inclusion criteria for the screening, 134 cases were enrolled in the study among 234 newly registered cases since September 1, 2017. Among the 73 patients who met the inclusion criteria, 40 patients who had smart phones and could stay online during the medication period (6 months) and were willing to use WeChat APP to remind them to take the medication were included in the WeChat APP group. Of the 94 patients who did not have smart phones or had smart phones, but willing to use the medicine monitor, 80 pationts who were willing to use the medicine monitor for medication reminder were included in the medicine monitor group. Two groups of patients were prospectively monitored and administered medication for 6 months. SPSS 17.0 software was used to conduct trend Chi-square test on the drug taking rate and regular drug compliance rate of patients in different treatment months in the two groups. P<0.05 was considered as statistically significant difference.Results During the observation period, 34 patients in the two groups withdrew, and the withdrawal rate was 28.3% (34/120), in which 29 patients in the medicine monitor group and 5 patients in the WeChat APP group in addition to 10 patients in the medicine monitor group with incomplete medication data. At the end of 6 months, 41 and 35 patients in the medicine monitor group and WeChat APP group were observed effectively. The drug taking rate of the two groups was more than 93.0% in different months, while the drug taking rate decreased as the treatment month increased, the drug taking rate in the medicine monitor group (97.5% (1025/1051)-93.3% (1110/1190)) and the WeChat APP group (99.5% (994/999)-94.4% (1018/1078)). {\chi }_{\mathrm{trend}}^2 were 11.868 and 82.921, P values were 0.001 and 0.000 respectively. The overall regular medication rate was 85.4% (35/41) among the effective observation cases of the medicine monitor group and 91.4% (32/35) in the WeChat APP group.Conclusion The supervision medication management mode of WeChat APP and medicine monitor have good effect on the medication rate and compliance of patients, which can be rolled out.

Key words: Tuberculosis, pulmonary, Drug therapy, Case management, Outcome and process assessment (health care), Mobile phone WeChat, Medicine monitor