Abstract: Objective To evaluate the therapeutic effect of sparfloxacin (SPLX)on multidrug resistant pulmonary tuberculosis (MDR-PTB).Methods 104 cases of MDR-PTB were allocated at random pair to two groups,using domestic ofloxacin (OFLX) as comparison.52 cases were treated with the regimen of 3SHRZE+SPLX/9HRE+SPLX.52 cases were treated with the regimen of 3SHRZE+OFLX/9HRE+OFLX.Results At the end of treatment,the sputum negative conversion rates of treatment group were 92.3%,while the rates of control group were 69.2%, P＜0.05,after two months treatment the difference of the sputum negative conrersion rate in the treatment group was statistically significant when compared with the control group (P＜0.01) .Conclusion Sparfloxacin is an effective drug in treating patients with MDR-PTB among other quinolones.

Key words: Tuberculosis,pulmonary/drug therapy, Multidrug, Resistant Sparfloxacin