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Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (5): 409-417.doi: 10.3969/j.issn.1000-6621.2020.05.001

• Guideline·Standard·Consensus •     Next Articles

Guideline for clinical application of clofazimine in the treatment of tuberculosis

Beijing Chest Hospital,Capital Medical University, Clinical Trial Branch of the Chinese Antituberculosis Association, Editorial Board of Chinese Journal of Antituberculosis   

  • Received:2020-02-29 Online:2020-05-10 Published:2020-05-08

Abstract:

Clofazimine, as one of the core drugs for the treatment of drug-resistant tuberculosis, lacks regulatory guideline. The Clinical Trial Branch of the Chinese Antituberculosis Association and the Editorial Board of Chinese Journal of Antituberculosis organized relevant experts to develop this guideline. This guideline formulated the molecular structure, mechanism of action, pharmacodynamics and pharmacokinetics, mechanism of drug resistance, indications and contraindications, dosage, chemotherapy regimen, adverse effect and precautions for clinical application to guide the clinical application for different population with clofazimine in practice.

Key words: Tuberculosis, Tuberculosis,multidrug-resistant, Clofazimine, Therapeutic uses, Practice guideline