Abstract: Objective To observe the epidemic trend of drug resistance of the smear positive tuberculosis in 1993～2000.Methods All of the strains of M.tuberculosis from new register smear positive tuberculosis were tested for resistance to INH RFP EMB SM by absolute concentration methods.Results The rate of initial resistance declined from 34.6% in 1993～1994 to 18.2% in 1999～2000.The resistance rate to SM and INH declined from 22.6%,13.2%in 1993～1994 to 13.4%,7.8% in 1999～2000 respectively.The rate of the acquired resistance declined from 52.1% in 1993～1994 to 35.7% in 1999～2000. The total drug resistance rate of MDR was 9.5% in 1993～1994 and 7.6% in 1999～2000.Conclusion The rate of initial and the acquired drug resistance was declined.The total rate of drug resistance of MDR did not decline.

Key words: M.tuberculosis, Drug resistance, Surveillance