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Chinese Journal of Antituberculosis ›› 2020, Vol. 42 ›› Issue (11): 1232-1236.doi: 10.3969/j.issn.1000-6621.2020.11.016

• Special Articles • Previous Articles     Next Articles

Epidemiology and preventive intervention of inactive tuberculosis

DU Ying*, ZHANG Bin, WANG Da-kuan, ZHANG Hao-ran, XIN He-nan, JIN Qi, GAO Lei()   

  1. *Institute of Pathogen Biology of Chinese Academy of Medical Science (PhD candidate), Beijing 100730, China
  • Received:2020-09-07 Online:2020-11-10 Published:2020-11-13
  • Contact: DU Ying,GAO Lei E-mail:gaolei@ipbcams.ac.cn

Abstract:

China is one of the countries with the highest burden of Mycobacterium tuberculosis (MTB) infection in worldwide with 350 million people were infected as estimated by Dr. Houben and colleagues using Gaussian process regression model. The guidelines on tuberculosis (TB) preventive treatment updated by the World Health Organization in 2020 recommended that “A history of prior TB or TB preventive treatment should not be a contraindication for preventive treatment in case of exposure, following the exclusion of reactivated disease. These individuals, including those with fibrotic radiological lesions, may be at increased risk of progression.” Individuals with chest radiography abnormalities suggestive of prior healed TB has been recommended as targets for latent tuberculosis infection (LTBI) testing and treatment in American and Canada. In countries and areas with high burden of TB,considering the potential high burden of inactive TB, enhancing active case finding and LTBI preventive treatment in this high-risk group might benefit TB incidence decline in a community level.

Key words: Mycobacterium tuberculosis, Inactive tuberculosis, Population surveillance, Protective agents