Abstract: Objective To explore the mechanism of MDR-TB and treatment regiment using second line antituberculosis drugs,to illustrate the effective mechanism of augmentin.Methods The standard and treatment outcome of MDR-TB designed by Chinese Antituberculosis Association was used to compare the curative effect of treatment regimens using second line antituberculosis drugs containing augmentin(expermental group)and without augmentin(control group) to treat 72 cases with MDR-TB admitted in our hospital in the last 10 years.Results The comparison of treatment outcome of the 72 MDR-TB cases showed that,after 6 months treatment the improving rate of chest X-ray and sputum conversion were more obvious in experimental group than in control group.There is significantly difference between the two groups (P＜0.05) .Conclusion Augmentin is new,effective and safe antituberculosis drug.

Key words: MDR-TB, Augmentin(Amxicillin/Clauvlanic Acid), Drug therapy