Abstract:

Objective To explore the treatment effect and influencing factors of initial treated smear-positive pulmonary tuberculosis patients in Kashgar Prefecture, and to improve the treatment success rate and provide references for formulating appropriate intervention measures. Methods With stratified cluster sampling method, 240 out of 4970 initial treated smear-positive pulmonary tuberculosis patients who were registered at tuberculosis designated hospitals in Kashgar Prefecture from 2016 to 2018 and completed treatment were selected as the research objects, 231 patients completed questionnaire survey, on-site interview and case investigation analysis. General demographic data, medication management, treatment outcomes and adverse reactions were collected. Univariate and multivariate logistic regression models were used to analyze the treatment effect and its influencing factors of the enrolled patients. Results Among the 231 cases who completed the survey, 179 cases were successfully treated (77.49%, 179/231). Multivariate logistic regression analysis showed that BMI 18.50-24.00 (OR=0.036, 95%CI: 0.002-0.700), sputum smear negative after two months treatment (OR=0.054, 95%CI: 0.003-0.930), sputum smear negative after five months treatment (OR=0.003, 95%CI: 0.000-0.057), taking medication according to the dose (OR=0.013, 95%CI: 0.001-0.107), regular medication (OR=0.077, 95%CI: 0.022-0.268), knowing the route of transmission of tuberculosis (OR=0.076, 95%CI: 0.008-0.768) and when the treatment can be stopped (OR=0.254, 95%CI: 0.074-0.875) were the protective factors for the treatment effect of patients. Conclusion The treatment success rate of initial treated smear-positive pulmonary tuberculosis patients in Kashgar Prefecture is relatively low, which is related to the nutritional status of patients, follow-up sputum examination results, medication according to the dose and schedule, and the patients’ awareness of prevention and treatment. The treatment management, nutritional support and health education of initial treated smear-positive pulmonary tuberculosis patients in Kashgar Prefecture should be further strengthened to improve the treatment success rate of the initial treated smear-positive pulmonary tuberculosis patients.

Key words: Tuberculosis, pulmonary, Treatment outcome, Factor analysis, statistical