Research progress on the correlation between intestinal microbiota short chain fatty acids and pulmonary tuberculosis

doi:10.19982/j.issn.1000-6621.20230079

Abstract

Abstract:

Short chain fatty acids (SCFA) are the main metabolites of the gut microbiota, mainly including formic acid, acetic acid, propionic acid, butyric acid and their branched chain fatty acids, and some salts. Research has shown that there is a significant direct correlation between SCFA and the occurrence and development of pulmonary tuberculosis. Pulmonary tuberculosis leads to imbalance of gut microbiota, thereby reducing the abundance of SCFA, which affects the host immune system and the response of inflammatory factors; the disorder of host immune system and inflammatory factor will promote the occurrence and development of pulmonary tuberculosis.The author reviewed the correlation between SCFA and pulmonary tuberculosis, the possible regulatory mechanism between them, and whether it was possible to improve the abundance of SCFA in the body by regulating intestinal flora to achieve the purpose of treatment or adjuvant treatment of pulmonary tuberculosis.

Key words: Tuberculosis, pulmonary, Enterobacteriaceae, Short-chain fatty acids, Immune system

CLC Number:

Zhang Xiaomeng, Li Min, Chai Yinghui, Zhou Jing, Lei Hong. Research progress on the correlation between intestinal microbiota short chain fatty acids and pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(7): 699-706. doi: 10.19982/j.issn.1000-6621.20230079

Figures/Tables 2

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疾病	短链脂肪酸(SCFA)	参考文献
过敏性哮喘	乙酸、丁酸	[24-25]
肠道炎症	乙酸、丙酸、丁酸	[26?-28]
多发性硬化症	丙酸	[17]
肥胖疾病	丙酸	[18-19]
糖尿病	乙酸、丁酸	[20]
心血管疾病	丙酸、丁酸	[21]
癌症	乙酸、丙酸、丁酸	[22-23]
骨质疏松症	丁酸	[29]
肺部疾病	乙酸、丙酸、丁酸	[6?-8]