Abstract:

Objective: To analyze the epidemiological characteristics of Mycobacterium tuberculosis and HIV (MTB/HIV) co-infection in Henan, in order to provide a scientific basis for the prevention and control in the Henan and even in China. Methods: Data of co-infection in Henan from 2016 to 2021 were collected from the Annual Report of Prevention and Management of MTB/HIV co-infection in Henan Province, the statistical descriptive methods and chi-square test for linear trend were used to analyze the rate of bi-directional screening, registration, the distribution and change tendency of MTB/HIV co-infection from 2016 to 2021 in Henan. Results: Of the 591960000 permanent resident population in Henan, 290450 tuberculosis (TB) and 387785 HIV/AIDS patients were registered from 2016 to 2021. Among them, 1756 were MTB/HIV co-infection, the average annual registration rate was 0.30/100000 (1756/591960000), accounting for 0.60% (1756/290450) of TB and 0.45% (1756/387785) of HIV/AIDS patients. The detection rate of TB diagnosis from HIV/AIDS patients decreased from 0.46% (263/57116) in 2016 to 0.28% (199/69862) in 2021, and HIV antibody detected positive from TB patients decreased from 0.17% (47/27955) in 2016 to 0.10% (21/21914) in 2021, the registration rate of MTB/HIV co-infection decreased from 0.32/100000 (310/97780000) in 2016 to 0.22/100000 (220/98830000), showing a fluctuating downward trend ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=49.965, 44.786 and 38.841, respectively; all Ps<0.001). The proportion of MTB/HIV co-infected patients in male was significantly higher than that in female (78.72% (1365/1734) vs. 21.28% (369/1734)) from 2016 to 2021, but the difference in the proportion of male and female in the past five years was not significant ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=5.137, P=0.399). Meanwhile, the average annual registration rate of MTB/HIV co-infection in Zhengzhou and Zhoukou increased from 0.38/100000 (43/11190000) and 0.15/100000 (14/9220000) in 2016 to 0.46/100000 (58/127420000) and 0.26/100000 (23/88530000) in 2021, respectively, showing a fluctuating upward trend in each year ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=26.088, P<0.001; {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=15.536, P=0.008). Conclusion: The number of MTB/HIV co-infected patients in Henan showed a decreased trend year by year from 2016 to 2021, indicating that the MTB/HIV co-infection was effectively controlled, however, attention should be paid to the infection in male, as well as in the cities of Zhengzhou and Zhoukou.

Key words: Mycobacterium tuberculosis, HIV infections, Comorbidity, Epidemiologic study characteristics as topic