γ-干扰素诱导蛋白10在结核性胸膜炎辅助诊断中的应用价值

中国防痨杂志 ›› 2013, Vol. 35 ›› Issue (2): 108-110.

γ-干扰素诱导蛋白10在结核性胸膜炎辅助诊断中的应用价值

任卫聪聂理会姜晓颖刘毅孙照刚张旭霞田苗程君张健源李传友

101149首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所细菌免疫室

收稿日期:2012-12-19 出版日期:2013-02-10 发布日期:2013-05-13
通信作者: 李传友 E-mail:lichuanyou6688@hotmail.com

Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions

REN Wei-cong, NIE Li-hui, JIANG Xiao-ying, LIU Yi，SUN Zhao-gang, ZHANG Xu-xia, TIAN Miao, CHENG Jun, ZHANG Jian-yuan, LI Chuan-you

Department of Bacteriology and Immunology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital University of Medicine, Beijing 101149, China

Received:2012-12-19 Online:2013-02-10 Published:2013-05-13
Contact: LI Chuan-you E-mail:lichuanyou6688@hotmail.com

摘要/Abstract

摘要： 目的探讨胸腔积液γ-干扰素诱导蛋白10（IP-10）在结核性胸膜炎中的诊断价值。方法选择2010年10月至2011年10月在北京胸科医院门诊及收住入院的胸腔积液患者195例，其中结核性胸腔积液患者112例(结核性胸腔积液组)，恶性肿瘤胸腔积液患者83例（恶性胸腔积液组），采用双抗夹心酶联免疫吸附测定法(ELISA)检测患者胸腔积液IP-10浓度，研究两组患者IP-10浓度的差异。结果结核性胸腔积液组IP-10浓度［196 855（4518～1 512 550） pg/ml］明显高于恶性胸腔积液组［7432（173～97881）pg/ml］，差异有显著统计学意义（U=575.00，P<0.001）；结核性胸腔积液组IP-10阳性患者构成比为82.14%（92/112），恶性胸腔积液组IP-10阳性患者构成比为6.02%（5/83），两组比较差异有显著统计学意义（χ²=110.49，P<0.001）。ROC曲线分析结果显示，胸腔积液中IP-10的诊断临界值为10 964 pg/ml，诊断敏感度为82.14%（92/112），特异度为93.98%(78/83)，准确度为87.18%(170/195)。结论胸腔积液IP-10水平检测对结核性胸膜炎的早期诊断与鉴别诊断具有重要价值。

关键词: 结核, 胸膜/诊断, 趋化因子CXCL10

Abstract: Objective To study the diagnostic value of interferon-γ inducible protein 10 (IP-10) level in tuberculous pleural fluid. Methods Between October 2010 and October 2011,195 patients adimitted to Beijing Chest Hospital were recruited consecutively, 112 tuberculous pleural effusions and 83 malignant pleural effusions were measured the IP-10 level by enzyme-linked immunosorbent assay（ELISA）. Results The IP-10 levels were significantly higher in tuberculous pleural effusions compared with malignant pleural effusions, and their difference was significant ［196 855（4518-1 512 550） pg/ml vs. 7432（173-97 881） pg/ml, U=575.00, P<0.001］. Using a cut off value of 10 964 pg/ml estimated from IP-10 receiver operating characteristic analysis, the sensitivity, specificity and efficiency of IP-10 were 82.14%（92/112）, 93.98% (78/83)and 87.18%(170/195),respectively. Conclusion The IP-10 level in pleural effusion is significant for the early diagnosis and differential diagnosis.

Key words: Tuberculosis, pleural/diagnosis, Chemokine CXCL10

任卫聪聂理会姜晓颖刘毅孙照刚张旭霞田苗程君张健源李传友. γ-干扰素诱导蛋白10在结核性胸膜炎辅助诊断中的应用价值[J]. 中国防痨杂志, 2013, 35(2): 108-110.

REN Wei-cong, NIE Li-hui, JIANG Xiao-ying, LIU Yi，SUN Zhao-gang, ZHANG Xu-xia, TIAN Miao, CHENG Jun, ZHANG Jian-yuan, LI Chuan-you. Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions[J]. Chinese Journal of Antituberculosis, 2013, 35(2): 108-110.

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